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Method for preparing composite phospholipid sterol lipid

A technology of compounding phospholipids and lipids, which is applied in the directions of liposome delivery, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of waste of resources, inability to control product quality, limitation of technical parameters, etc., and achieve excellent stability Effect

Active Publication Date: 2012-08-22
河北格川科技发展集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Since the technical method does not limit the relevant technical parameters, the product quality cannot be controlled during the production process.
Create a large number of waste products, causing a great waste of resources

Method used

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  • Method for preparing composite phospholipid sterol lipid
  • Method for preparing composite phospholipid sterol lipid
  • Method for preparing composite phospholipid sterol lipid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Preparation of complex phospholipid sterol lipids

[0057] 1. Prescription

[0058]

[0059] 2. Process:

[0060] 1. Weigh 82.4g of refined soybean lecithin, 17.5g of cholesterol and 0.1001g of vitamin E, dissolve them with absolute ethanol, and mix well.

[0061] 2. Place the lipid solution on a rotary evaporator, and remove absolute ethanol under reduced pressure to obtain lipid lumps.

[0062] Total weight: 99.1g (99.1% yield)

[0063] The mass ratio of cholesterol to soybean phospholipids is 0.204

Embodiment 2

[0065] prescription:

[0066]

[0067] operate:

[0068] 1. Weigh 18.2g of soybean lecithin, 3.9g of cholesterol and 0.0112g of vitamin E into a beaker, dissolve them with absolute ethanol, mix well, and filter.

[0069] 2. Place the lipid solution on a rotary evaporator, remove absolute ethanol under reduced pressure to form a film, and obtain lipid lumps.

[0070] Total weight: 21.3g (96.8% yield)

[0071] The mass ratio of cholesterol to soybean phospholipids is 0.211

Embodiment 3

[0073] prescription:

[0074]

[0075] operate:

[0076]1. Weigh 165.1g of soybean lecithin, 35.2g of cholesterol and 0.2019g of vitamin E, dissolve them with absolute ethanol, mix well, and filter.

[0077] 2. Place the lipid solution on a rotary evaporator, remove absolute ethanol under reduced pressure to form a film, and obtain lipid lumps.

[0078] Total weight: 197.4g (98.7% yield)

[0079] The mass ratio of cholesterol to soybean phospholipids is 0.213

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PUM

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Abstract

The invention relates to a method for preparing composite phospholipid sterol lipid. The preparation method comprises the following steps of: 1, weighing soybean phospholipid, cholesterol and vitamin E, dissolving by using absolute ethyl alcohol, uniformly mixing and filtering; and 2, putting the lipid solution on a rotary evaporator, decompressing, removing the absolute ethyl alcohol, and forming a film to obtain lipid lumps.

Description

Technical field: [0001] The invention relates to a preparation method of liposome, in particular to a preparation method of complex phospholipid sterol lipid. Background technique: [0002] Liposome is an artificial membrane. In the water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends to the air. After stirring, a spherical liposome of bilayer lipid molecules is formed, with a diameter ranging from 25 to 1000 nm. Liposomes can be used for genetically modified or prepared drugs, using the characteristics of liposomes that can fuse with cell membranes to deliver drugs into cells Biological definition: when amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the water phase, the hydrophobic The tails tend to clump together, avoiding the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming closed vesicles with a bilayer structure called lip...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/405A61P27/02
Inventor 史雪燕
Owner 河北格川科技发展集团有限公司