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Preparing method and detecting method for fructus trichosanthis granules

A technology of Gualou Xiebai and a detection method is applied in the field of preparation and detection of Gualou Xiebai granules, and can solve the problems that the quality of Gualou Xiebai granules cannot be accurately and comprehensively evaluated, and the quality of traditional Chinese medicine cannot be evaluated comprehensively and objectively, and high stability is achieved. , the effect of overall particle quality

Inactive Publication Date: 2014-02-26
WANNAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the compound Chinese medicine is a complex medication system, especially according to the idea of ​​the holistic view of Chinese medicine, the efficacy of Chinese medicine is achieved through multiple components acting on multiple targets in the body, even if several components are used as quality control at the same time. It is still not enough to comprehensively and objectively evaluate the quality of traditional Chinese medicine, let alone using a single component, so the quality of Gualou Xiebai Granules cannot be accurately and comprehensively evaluated by using Xiebai saponin B

Method used

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  • Preparing method and detecting method for fructus trichosanthis granules
  • Preparing method and detecting method for fructus trichosanthis granules
  • Preparing method and detecting method for fructus trichosanthis granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 90g of Trichosanthes melon and 90g of Xiebai herbs, crush them, add 1000ml of water, decoct for 2 hours, extract 3 times, combine and extract the medicinal liquid, filter, and concentrate the filtrate to a clear paste with a relative density of 1.05 to 1.15 under normal pressure, reduce Press and dry, and grind into dry powder to obtain about 18g of Melonium scallops extract, add 3 grams of lactose, use 10ml of 80% ethanol to make a soft material, make granules, dry under normal pressure at 60°C, granulate, and get melons Lou Xiebai granules are divided into bags, and the specification is that every 1 gram is equivalent to 5 grams of Gualou and Xiebai medicinal materials.

Embodiment 2

[0040] Take 90g of Trichosanthes mellifera and Xiebai medicinal materials, soak in 1000ml of ethanol solution with a volume concentration of 75%-80% for 1h, ultrasonically (KH-4-DB type numerical control ultrasonic cleaner, Kunshan Hechuang Ultrasonic Instrument Co., Ltd.) for 45min, filter, and the filtrate Concentrate to a thick paste and set aside. The residue was soaked in 800ml of 65%-75% ethanol solution for 1 hour, ultrasonically treated for 45 minutes, filtered, and the filtrate was concentrated to a thick paste for later use. The residue was soaked in 600ml of 55%-65% ethanol solution for 1h, ultrasonically treated for 45min, filtered, the filtrate was concentrated to a thick paste, and three thick pastes were combined (relative density was 1.10-1.25) to obtain about 30g of Gualou Xiebai extract. Add an appropriate amount of soluble starch to make soft materials, and then make granules, dry under normal pressure at 60°C, and granulate to obtain Gualou Xiebai granules,...

Embodiment 3

[0042]Take 90g of Trichosanthes melon and 90g of Xiebai herbs, crush them, add 1000g of 60% ethanol, decoct for 3 hours, extract 3 times, combine and extract the medicinal liquid, filter, and concentrate the filtrate to a clear liquid with a relative density of 1.05-1.15 under normal pressure. Paste, dry under reduced pressure, grind into dry powder, obtain about 25g of the extract of Fructus Albae, add 5 grams of β-cyclodextrin, make a soft material with 8ml of 80% ethanol, make granules, and dry under normal pressure at 60°C. Whole grains, Gualou Xiebai granules are obtained, and packed into bags, the specification is that each gram is equivalent to 10 grams of Gualou and Xiebai medicinal materials.

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Abstract

The invention discloses a preparing method and a detecting method for fructus trichosanthis granules. The preparing method comprises the following steps of: (a) preparing an extract; and (b) preparing granules. The detecting method is a fingerprint chromatography method. Compared with the prior art, the active components of the prepared granules have high stability according to the preparing method and the detecting method for the fructus trichosanthis granules. The quality of a traditional Chinese medicine is controlled by the detecting method through adopting a fingerprint chromatography technology. The preparing method and the detecting method for the fructus trichosanthis granules are more suitable for the concept of holistic view of traditional Chinese medicine and have the characteristic of evaluating the quality of the fructus trichosanthis granules more comprehensively.

Description

technical field [0001] The invention belongs to the preparation and detection method of traditional Chinese medicine prescriptions, in particular to the preparation method and detection method of Gualou Xiebai Granules. Background technique [0002] Traditional Chinese medicine plays an increasingly prominent role in the prevention and treatment of cardiovascular diseases. Gualou Xiebai Baijiu Soup is composed of three traditional Chinese medicines, Gualou, Xiebai and Baijiu. 》, is a representative prescription used by traditional Chinese medicine for the treatment of thoracic obstruction, and is also one of the basic prescriptions used for the treatment of cardiovascular diseases in recent years. The bioavailability of Xiebai is low, and the stability of the active ingredients is not easy to control; Gualou Xiebai Decoction is placed at room temperature for 7 days, and the contents of total alkaloids and total saponins are significantly reduced; [0003] For Gualou Xiebai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61K9/16G01N30/02A61P9/00
Inventor 鄢海燕邹纯才
Owner WANNAN MEDICAL COLLEGE
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