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Gamuzhuer medicinal latex preparation and preparation method thereof

A Gamuzhuer emulsion technology, applied in the field of Gamujuer emulsion and its preparation, can solve the problems of high irritation of anionic emulsifiers, difficulty in forming suppositories, and strong irritation of alcohol, etc., so as to accelerate the onset of effect time, administration convenience, and the effect of prolonging the action time

Inactive Publication Date: 2012-08-29
SHENZHEN JIAXUAN MEDICAL TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are also studies to make it into suppositories to facilitate its gynecological application, but because the compound contains minerals and the dosage is large, the forming of the suppositories is difficult and difficult to prepare
Chinese patent 200610112027.5 relates to a Mongolian medicine for treating gynecological inflammation. During the preparation process, alcohol is used to extract the active ingredients of traditional Chinese medicine, and the residual alcohol is also highly irritating; and sodium lauryl sulfate is used as an emulsifier during preparation, and anion Emulsifiers are also more irritating

Method used

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  • Gamuzhuer medicinal latex preparation and preparation method thereof
  • Gamuzhuer medicinal latex preparation and preparation method thereof
  • Gamuzhuer medicinal latex preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] According to the Mongolian Medicine Pharmacopoeia, take the cold water stone, realgar, stone cassia, cinnabar, silver beads, musk, and borneol in proportion, grind them into fine pieces, pass through a primary sieve of 80 mesh, and pulverize by jet to obtain the required micronized main medicine.

[0035] The Gamuzhuer is composed of 7 medicines including cold water stone, realgar, cinnabar, cinnabar, cassia stone, borneol and musk, and the weight parts of each component are:

[0036] 35 parts of cold water stone, 10 parts of realgar, 5 parts of cinnabar, 5 parts of silver vermilion, 5 parts of stone cassia, 25 parts of borneol, 0.5 part of musk;

[0037] The particle size of the powder was measured by laser diffraction method, and the specific particle size distribution is shown in the following table.

[0038] Sample

Embodiment 2

[0040] (1) Weigh 97.5 g of Gamjur of Example 1, 150 g of glycerin, and 10 g of Tween 80 and mix them evenly;

[0041] (2) Take 2.5 g of the bioadhesive sodium alginate and swell with 64 g of water, add it to step (1) Gamjur, and mix;

[0042] (3) Take 30g stearyl alcohol, 20g white petrolatum, 20g glyceryl monostearate, 30g liquid paraffin, 20g lanolin, 30g simethicone, mix and heat to 60℃; add 5g Span 80, 5g Tween 80 and 16g water, stir, let cool to obtain emulsion;

[0043] (4) Mix the mixture of step (2) and the emulsion of step (3) uniformly, with a total weight of 500 g, and distribute them to obtain.

Embodiment 3

[0045] (1) Weigh 200 g of Gamjur from Example 1, 100 g of glycerin, and 10 g of Tween 80 and mix them evenly;

[0046] (2) Take 0.25 g of sodium carboxymethyl cellulose as a bioadhesive agent, swell it with 25 g of water, and add it to step (1) Gamjur and mix;

[0047] (3) Take 30g of white petrolatum, 20g of glyceryl monostearate, 30g of liquid paraffin, and 20g of simethicone, mix and heat to 50°C; add 4.75g of Tween 80 and 60g of water, stir and let cool to obtain an emulsion;

[0048] (4) Mix the mixture of step (2) and the emulsion of step (3) uniformly, with a total weight of 500 g, and distribute them to obtain.

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Abstract

The invention provides a Gamuzhuer medicinal latex preparation and a preparation method thereof. The Gamuzhuer medicinal latex preparation comprises the following components by weight percentage: 10-40% of Gamuzhuer, 0.1-8% of bioadhesive agent, 0.1-5% of non-ionic emulsifier, 1-30% of glycerol, 0-30% of grease and the balance of water. The bioadhesive material is bond with the Gamuzhuer, so thatmedicines are dispersed and adhered to a focus part so as to achieve a therapeutic aim; the Gamuzhuer latex preparation has a higher content, is more convenient to administer and is not added with any irritant solvent; the acting time is prolonged; during preparation, a proper amount of emulsifier is added, so that dissolution of musk and borneol can be promoted; compared with the conventional powdery preparation, the latex preparation takes effect more quickly; a proper amount of grease and a proper amount of emulsifier are added to achieve a good lubricating effect; the grain diameter of the medicinal powder is optimized, so that 99 percent of the powder is smaller than 100 um and thus the stability of the medicinal powder is improved; and the medicines have antibacterial and antisepticfunctions, so that a preservative is not required.

Description

Technical field [0001] The invention relates to a Gamuzul emulsion and a preparation method thereof. Background technique [0002] The traditional Mongolian medicine Gamuzhuer belongs to the classic Mongolian medicine prescription, and it has been used for many years in the clinical frontline of Inner Mongolia. Gamuzhuer is composed of 7 medicines such as borneol, realgar, cinnabar, cinnabar, cassia stone, cold water stone, and musk. It has the functions of muscle growth and astringency. It is used for sores, ulcers, throat swelling and skin. Festering, traumatic infection, cervical erosion and other diseases. Gamuzhuer is a compound preparation, of which 5 ingredients have been included in the 2005 edition of the Chinese Pharmacopoeia. They are realgar, cinnabar, stone cassia, borneol and musk. Most of them are for reducing swelling and pain, promoting blood circulation and dysmenorrhea, and resuscitating the mind , Detoxification insecticide. Yinzhu is recorded in the "Compe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/00A61K47/44A61P11/04A61P15/00A61P17/02A61K31/045A61K33/06A61K33/28A61K33/36A61K35/55A61K35/618
Inventor 孔徐生金方雷伯开闻聪王玉杰
Owner SHENZHEN JIAXUAN MEDICAL TECH DEV
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