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Iloperidone medicine composition and preparation method thereof

A technology of iloperidone and drugs, applied in the field of pharmaceutical preparations, can solve the problems of low dissolution of iloperidone and achieve the effect of improving the dissolution rate

Inactive Publication Date: 2015-01-21
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of low dissolution of the insoluble drug iloperidone in the prior art, and provide a new fast-dissolution iloperidone pharmaceutical preparation, the dissolution rate of which can reach more than 90% in 5 minutes.

Method used

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  • Iloperidone medicine composition and preparation method thereof
  • Iloperidone medicine composition and preparation method thereof
  • Iloperidone medicine composition and preparation method thereof

Examples

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Effect test

Embodiment 1

[0025] components

[0026] Preparation process: weigh iloperidone, lactose, microcrystalline cellulose, povidone and crospovidone according to the prescription amount, and mix well. Use water as a binder, granulate, and dry at 60°C. Add magnesium stearate, mix, and compress into tablets.

Embodiment 2

[0028] components

[0029] Preparation process: weigh iloperidone, lactose, microcrystalline cellulose, povidone and carboxymethyl starch sodium according to the prescription amount, and mix them evenly. Use water as a binder, granulate, and dry at 60°C. Add magnesium stearate, mix, and compress into tablets.

Embodiment 3

[0031] components

[0032] Preparation process: weigh iloperidone, lactose, microcrystalline cellulose, povidone and croscarmellose sodium according to the prescription amount, and mix them evenly. Use water as a binder, granulate, and dry at 60°C. Add magnesium stearate, mix, and compress into tablets.

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Abstract

The invention belongs to the technical field of iloperidone medicine preparations. In the iloperidone medicine composition provided by the invention, the auxiliary medicines include two or more disintegrating agents; the iloperidone exists in the form of particles; and the particle size of at least 90% of the particles is less than 50mm, most preferably less than 20mm. In the invention, the dissolution rate of the medicine in 5 minutes can be improved by using composite disintegrating agents and controlling the particle size, the aim of fast dissolution of the medicine is achieved, and the medicine takes an effect quickly.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular, the invention relates to a fast-release iloperidone pharmaceutical preparation. Background technique [0002] Iloperidone is an antipsychotic drug registered by Vanda Pharma in the United States. It was approved by the FDA on May 6, 2009 and listed in the United States. The foreign trade name is For the treatment of schizophrenia in adults. Iloperidone, as an oral atypical antipsychotic drug, is effective in alleviating positive symptoms (such as hallucinations, delusions, disordered thinking, hostility, suspicion) and negative symptoms (such as unresponsiveness, apathy, social apathy, less language) have obvious effects. Compared with the currently used antipsychotic drugs, the results of short-term and long-term safety trials show that iloperidone has fewer adverse reactions, the patient's weight gain is smaller, iloperidone will not induce diabetes in pati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/454A61K47/38A61K47/36A61K47/32A61P25/18
Inventor 孟小弟时惠麟钟静芬张庆
Owner SHANGHAI INST OF PHARMA IND CO LTD