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A kind of antibacterial agent for external application containing camptothecin and its preparation method and application

A technology of camptothecin and medicament, which is applied in the field of external antibacterial medicament containing camptothecin and its preparation, to achieve the effect of simple application, low production cost and improvement of microcirculation

Inactive Publication Date: 2017-09-26
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are few studies on camptothecin in the development of external antibacterial agents. We found that camptothecin has inhibitory and killing effects on fungi, bacteria, mold rot, and viruses, and can be combined with a series of traditional Chinese medicines. Combination of active substances can improve the antibacterial activity and have a significant effect on skin ringworm

Method used

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  • A kind of antibacterial agent for external application containing camptothecin and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Add 130g camptothecin, 80g leech, 110g Houttuynia cordata, 100g scorpion, 110g forsythia, 90g hippocampus, 70g ground beetle, 90g capillary, 80g turtle shell, 50g borneol and 130g beeswax into a clean 2L container, mix well , crushed into 100-mesh fine powder, soaked in enough water for 8 hours, heated to 80°C for 20 minutes, then vacuum filtered to remove the drug residues, collected the filtrate, then flashed the filtrate in a concentration device and dried it into Dry powder, finally grind into 80-mesh extract fine powder, and finally add 170g of medical alcohol to mix and dissolve to form the final product.

Embodiment 2

[0021] Add 100g camptothecin, 50g leech, 70g Houttuynia cordata, 70g scorpion, 90g forsythia, 70g hippocampus, 50g ground beetle, 60g capillary, 50g turtle shell, 40g borneol and 100g beeswax into a clean 2L container, mix well , crushed into 200-mesh fine powder, soaked in enough water for 15 hours, heated to 110°C for 40 minutes, vacuum filtered to remove medicinal residues, collected filtrate, and then flashed and concentrated the filtrate in a concentrating device and dried it into Dry powder, finally grind into 100-mesh extract fine powder, finally add 130g of medical alcohol to mix and dissolve, and the final product is made.

Embodiment 3

[0023] Add 150g camptothecin, 100g leech, 130g Houttuynia cordata, 110g scorpion, 130g forsythia, 100g hippocampus, 80g cuttlefish, 100g capillary, 90g turtle shell, 60g borneol and 150g beeswax into a clean 2L container, mix well , crushed into 150-mesh fine powder, soaked in enough water for 10 hours, heated to 100°C for 30 minutes, then vacuum filtered to remove the drug residue, collected the filtrate, then flashed the filtrate in a concentrator and dried it into Dry powder, finally grind into 90-mesh extract fine powder, and finally add 180g of medical alcohol to mix and dissolve to form the final product.

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Abstract

An external antibacterial agent containing camptothecin, its preparation method and application, belong to the technical field of traditional Chinese medicine external preparations. It is characterized in that it contains the following substances in weight percent: 8-17 parts of camptothecin, 3-11 parts of leech, 6-15 parts of Houttuynia cordata, 5-13 parts of scorpion, 8-15 parts of forsythia, 5-12 parts of hippocampus 3-9 parts of ground soft-shelled turtle, 5-12 parts of capillary wormwood, 4-11 parts of tortoise shell, 3-8 parts of borneol, 8-17 parts of beeswax, and 10-20 parts of medical alcohol. The above-mentioned external antibacterial agent containing camptothecin and its preparation method and application have the effects of antibacterial and antipruritic, pain relief and tinea dispelling, detoxification and dampness, anti-inflammation and detumescence, and improvement of microcirculation in the affected area. The medicine has remarkable curative effect on itching, swelling and pain of ringworm, tinea manus and pedis, tinea versicolor, ringworm rash, etc., has high cure rate, little toxic and side effects, simple preparation method, safe and effective, and low production cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations for external use, and in particular relates to a camptothecin-containing antibacterial agent for external use, a preparation method and application thereof. Background technique [0002] Camptothecin is a kind of pyrroloquinoline alkaloid, which is mainly derived from the deciduous tree Camptotheca involucrataceae which is endemic to my country and distributed in the Yangtze River Basin and Southwest provinces. A large number of studies have been conducted on the pharmacological activity and clinical application of camptothecin at home and abroad, and it is found that camptothecin is a special anti-tumor drug. It shows strong anticancer activity against HeLa cells, L1210 cells and rodents in vitro. The target of camptothecin is topoisomerase I (topoI), and its mechanism of action is to block topoI, thereby blocking DNA synthesis and achieving the effect of killin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61P17/00A61P31/04A61P31/10A61K35/64A61K35/62A61K35/586A61K31/4745A61K31/045A61K35/60A61K35/646A61K35/644
Inventor 毛胜凤张立钦马良进童森淼
Owner ZHEJIANG FORESTRY UNIVERSITY
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