Monoclonal antibodies against Enterovirus 71 and uses thereof

A technology of enterovirus and antibody, applied in the field of nerve cell protection and immunology

Active Publication Date: 2012-10-03
NAT INST OF HEALTH REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES NAT INST OF HEALTH
View PDF8 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no single-source antibody available that can specifically fight against the genotype B enterovirus 71 strain that has circulated in Taiwan, China in recent years

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Monoclonal antibodies against Enterovirus 71 and uses thereof
  • Monoclonal antibodies against Enterovirus 71 and uses thereof
  • Monoclonal antibodies against Enterovirus 71 and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0041] In another specific embodiment of the present invention, the monologous antibody is an antibody fragment.

[0042] In another aspect, the present invention relates to a monogenic antibody or binding fragment thereof that binds to enterovirus (EV) type 71, which comprises: a) heavy chain complementation having the amino acid sequence set forth in SEQ ID NO: 70 The determining region 1 (CDR1) polypeptide, which is complementary to the heavy chain having the amino acid sequence set forth in SEQ ID NO: 71, the determining region 2 (CDR2) polypeptide; and b) having the amino group listed in SEQ ID NO: 72 or 73 A light chain CDR1 polypeptide having an acid sequence, a light chain CDR2 polypeptide having an amino acid sequence set forth in SEQ ID NO: 74 or 75, and a light chain CDR3 polypeptide having an amino acid sequence set forth in SEQ ID NO: 76 or 77.

[0043] In a specific embodiment of the present invention, the binding fragment comprises an Fv fragment.

[0044] In another ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to monoclonal antibodies, or binding fragments thereof that bind Enterovirus (EV) 71. Antibodies, fragments of such antibodies retaining EV71-binding ability, fully human or humanized antibodies retaining EV71-binding ability, and pharmaceutical compositions comprising such antibodies are disclosed. Isolated nucleic acids encoding the antibodies of the invention and host cells transfected therewith are also disclosed. Additionally, prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention are disclosed.

Description

technical field [0001] The present invention relates to the application in the field of immunology for nerve cell protection, in particular to a single-source antibody that binds and / or neutralizes enterovirus 71. Background technique [0002] Enterovirus 71 is a positive-sense RNA virus classified in the family Picornaviridae. Since the first case of EV71 infection in California, USA in 1969, the virus has regularly infected humans around the world. Infection with enterovirus 71 (and some of its genetically close counterparts, such as coxsackievirus 16 (CA16) and CA10), is known to cause a mild rash that may manifest as mouth, foot, and hand in infants and children disease (HFMD) / herpetic angina. Periodic outbreaks of enterovirus 71 infection pandemics in the Asia-Pacific region over the past 10-12 years have resulted in pulmonary edema / hemorrhage that kills many infected children. Among EV 71 genogroups, viruses of genogroups B and C have been isolated during the pandem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/10C12N15/13C12N1/15C12N1/19C12N1/21C12N5/10A61K39/42A61P31/14G01N33/569
Inventor 张熏文谢铎源庄再成刘家齐
Owner NAT INST OF HEALTH REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES NAT INST OF HEALTH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap