Adenovirus bivalent vaccine

A technology of adenovirus and virus particles, applied in the field of virus immunology, can solve problems such as difficulty in production, achieve the effects of preventing infection, improving safety and application range, and improving replication ability
CN111166875AInactive Publication Date: 2020-05-19GUANGZHOU N BIOMED LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU N BIOMED LTD
Publication Date
2020-05-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an adenovirus bivalent vaccine. The vaccine comprises a replication-deficient human adenovirus type 4 and a replication-deficient human adenovirus type 7. E1 and E3 genes of the replication-deficient human adenovirus type 4 and the replication-deficient human adenovirus type 7 are deleted, and partial coding frames of the E4 gene are replaced by corresponding coding framesof E4 gene of human adenovirus type 5. The vaccine can effectively stimulate an organism to generate a humoral immune response and a cellular immune response, generate specific neutralizing antibodieswith high titer, and is used for preventing infection of pathogens.
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Description

technical field

[0001] The invention belongs to the technical field of virus immunology, and in particular relates to an adenovirus bivalent vaccine. Background technique

[0002] Adenovirus (Adenovirus, Ad) is a double-stranded DNA virus with a genome length of about 35-40 kb. It is known that human adenoviruses are divided into 7 subgroups (A-G), including more than 50 serotypes (more than 90 genotypes), which mainly cause acute respiratory diseases (adenovirus B and C subgroups) and conjunctivitis after infection. (adenovirus subgroups B and D) and gastroenteritis (adenovirus subgroup F 41 and 42, G subgroup 52). Respiratory tract infections caused by adenoviruses are mostly caused by adenovirus types 3, 4, and 7. Ad4 and Ad7 mainly concentrated in army, school and other places where youths and adolescents gathered, and even resulted in the death of patients. However, there is no specific drug for the treatment of adenovirus infection, and only supportive treatment can...

Claims

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