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Novel drug application of cantaloupe seed oil

A technology for cantaloupe seeds and medicines, which is applied to the field of new medicinal uses of cantaloupe seed oil, can solve the problems of crude oil containing a lot of non-oil substances, cannot be eaten directly, and has a deep color, and achieves improved extraction rate, increased added value, and increased income. Effect

Active Publication Date: 2012-10-10
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the extracted crude oil contains more non-oil substances, the quality is poor, and the color is darker. It cannot be eaten directly like pressed crude oil. It must be refined before it can be eaten.

Method used

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  • Novel drug application of cantaloupe seed oil

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, preparation Hami melon seed oil soft capsule

[0029] 1. Preparation of cantaloupe seed oil

[0030] Hami melon seeds were crushed through a 20-mesh sieve and placed in a supercritical extraction device. The extraction conditions were: extraction pressure 35MPa, extraction temperature 40°C, outlet separation temperature 50°C, extraction time 180min, CO 2 The flow rate is 2L / min, and cantaloupe seed oil is obtained, and its yield is 29.3%.

[0031] for supercritical CO 2 The chemical composition of the extracted Hami melon seed oil was determined by gas chromatography / mass spectrometry. The Hami melon seed oil was separated by gas chromatography quartz capillary column, and the mass spectrometer was recorded by the mass spectrometer. Search the spectral library to determine its chemical structure, and determine its relative content by area normalization method. The results showed that the unsaturated fatty acid content of Hami melon seed oil was very hig...

Embodiment

[0043] Embodiment, Hami melon seed oil is to hypolipidemic effect of hyperlipidemic mice

[0044] 1. Experimental animals

[0045] Healthy Kunming mice (20-25g) were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. High-fat feed (containing 20% ​​lard) was provided by Beijing Keao Xieli Feed Co., Ltd.

[0046] 2. Establishment of hyperlipidemia mouse model and experiment of lowering blood lipid

[0047]After three days of adaptive feeding, 20 mice were randomly divided into three groups, 6 mice in the normal control group, half male and half male, were fed with normal feed, and 0.02ml / g normal saline was administered daily; 6 mice in the high-fat group, half male and half male , fed with high-fat feed, fed with 0.02ml / g normal saline every day; the sample group was 8, half male and half male, fed with high-fat feed, fed with 0.02ml / g cantaloupe seed oil every day, continuously administered for four weeks, and the last gavage After fasting without f...

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Abstract

The invention discloses novel drug application of cantaloupe seed oil to preparation of blood lipid lowering products. The invention further provides a blood lipid lowering product with the cantaloupe seed oil as an active component. During production and processing of cantaloupes, many skin seed resources are wasted, the status quo of deep processing of the cantaloupes is changed, a cantaloupe deep processing product with a high added value is provided, and the overall level of comprehensive utilization of the cantaloupes is improved. The novel drug application is beneficial to improving the development of cantaloupe industry, incomes of farmers are increased, and the added value of the cantaloupes is improved. The cantaloupe seed oil is extracted by supercritical CO2 manner, extracting efficiency is improved by optimizing conditions, the cantaloupe seed oil is prevented from oxidative rancidity by means of capsule package, mouse experiments prove that the cantaloupe seed oil has the effect of lowering blood lipid, and the novel drug application has good social and economic benefits in practical production.

Description

technical field [0001] The invention relates to a new medicine application of Hami melon seed oil. Background technique [0002] The effect of fatty acids on blood lipids depends on the length of its own carbon chain and the position and number of unsaturated bonds. Saturated fatty acids with 12-16 carbon atoms can significantly increase the levels of total cholesterol, triglycerides and low-density lipoproteins, while stearic acid with 18 carbon atoms does not increase the levels of total cholesterol and low-density lipoproteins. Oxidative modification of low-density lipoprotein is the initial cause of atherosclerosis, and when the content of monounsaturated fatty acids in low-density lipoprotein particles is high, its oxidation sensitivity is reduced. Monounsaturated fatty acids can also significantly reduce the level of total cholesterol and low-density lipoprotein, reduce the effect of free radical lipid superoxide in the body, thereby effectively preventing atheroscler...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61K9/48A61P3/06A61K131/00
Inventor 吴继红姚宇博廖小军胡小松庞雪莉
Owner CHINA AGRI UNIV
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