Application of hepatocyte growth factor in preparation of medicines for treating multiple sclerosis

A technology of hepatocyte growth factor and multiple sclerosis, applied in the field of pharmacy and medicine, to achieve the effect of broadening the scope of application
CN102716467AInactive Publication Date: 2012-10-10THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
Publication Date
2012-10-10
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses an application of a hepatocyte growth factor (HGF) and a medulla desmohemoblast stem cell (MSC)-containing conditioned medium (MSC-CM) in preparation of medicines for treating multiple sclerosis (MS). The research result shows that in a cord sheath oligodendrocyte glycoprotein 35-55 peptide fragments (MOG35-55) induced MS animal model EAE, human MSC paracrine substance-containing MSC-CM is provided to reduce the EAE functional defect, and the growth of oligodendrocyte and neuron can be promoted when the functional cells are injured, wherein the HGF which is released by MSC performs the main effect; the effect provided to HGF is similar with MSC-CM, and the growth and movement of oligodendrocyte and neuron can be stimulated, the cord sheath restoration capability can be enhanced, the pathology load of MS animal model (EAE) can be minimized, the disease recovery function can be promoted, and short HGF treatment on the EAE model is provided for continuously guiding the disease function improvement. According to the invention, the application scope of HGF and MSC-CM can be widened, an effective medicine is provided for clinical treatment of MS, and the deep exploitation of a novel high efficiency MS treatment medicine can be realized simultaneously.
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Description

Technical field

[0001] The invention belongs to the field of medicine and relates to the new use of hepatocyte growth factor in the pharmaceutical field. Background technique

[0002] Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that mainly affects young and middle-aged people (20-50 years old) in their prime. There are more than 2,500,000 MS patients in the world. The number of MS patients in my country was about 65,000 in 2004, and has shown a rapid growth trend in recent years. The exact cause of MS is still unknown. It is currently believed to be related to autoimmunity. Its clinical manifestations include extreme fatigue, double vision, loss of sexual function, numbness of limbs, difficulty walking, paralysis, etc. The biggest difference from other neurological diseases is the recurrence of initial clinical symptoms. relapsing-remitting,โ€ frequently promoting greater loss of function. At present, there is no radical cure for MS in m...

Claims

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