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Composition used for inhibiting bacteria generating novel beta lactamase

A technology of beta-lactamase and composition, applied in the directions of antibacterial drugs, active ingredients of heterocyclic compounds, medical preparations containing active ingredients, etc.

Active Publication Date: 2012-10-24
NANJING YOKO PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These compositions are generally invented compositions aimed at the drug resistance of the second and third generation cephalosporins. For how to protect the antibacterial activity of the fourth generation cephalosporins (cefepime) from being destroyed by extended-spectrum β-lactamases, No new compounds have been released yet

Method used

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  • Composition used for inhibiting bacteria generating novel beta lactamase
  • Composition used for inhibiting bacteria generating novel beta lactamase
  • Composition used for inhibiting bacteria generating novel beta lactamase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The anti-production composition of novel β-lactamase bacteria, 1000 prescriptions are: 1171g cefepime hydrochloride (1000g by cefepime weight), 537.5g tazobactam sodium (1000g by tazobactam weight) 500g).

[0016] The preparation process is to weigh cefepime hydrochloride and tazobactam sodium and mix them uniformly.

Embodiment 2

[0018] The anti-production composition of novel β-lactamase bacteria, 1000 prescriptions are: 1171g cefepime hydrochloride (1000g by cefepime weight), 358g tazobactam sodium (333g by tazobactam weight) ).

[0019] The preparation process is to weigh cefepime hydrochloride and tazobactam sodium and mix them uniformly.

Embodiment 3

[0021] The anti-production composition of novel β-lactamase bacteria, 1000 prescriptions are: 1171g cefepime hydrochloride (1000g by cefepime weight), 180g tazobactam sodium (167g by tazobactam weight) ).

[0022] The preparation process is to weigh cefepime hydrochloride and tazobactam sodium and mix them uniformly.

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PUM

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Abstract

The invention discloses a composition used for inhibiting bacteria generating novel beta lactamase. The composition is advantaged in that the active components of the composition comprise cefepime and tazobactam with a weight ratio of 2-6:1. According to the invention, the composition used for inhibiting the bacteria generating novel beta lactamase has a good inhibiting and / or killing effect against the bacteria generating novel CTX-M enzyme and AmpC enzyme, and is especially effective against bacteria with drug resistance to CTX-M enzyme and AmpC enzyme hydrolysis effects. The composition has good practicality, and provides good economic and social effects.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a composition against bacteria producing novel beta-lactamases (such as CTX-M enzyme and Amp C enzyme). Background technique [0002] Drug-resistant bacterial infection has become a major problem in the clinical treatment of infectious diseases. The fourth-generation cephalosporin cefepime has antibacterial activity against both Gram-negative bacilli and Gram-positive cocci, including Enterobacter cloacae, Enterobacter aerogenes, Klebsiella pneumoniae, Serratia, and Escherichia cocci bacteria, Pseudomonas aeruginosa, Proteus mirabilis, Proteus vulgaris, Enterobacter agglomerans, Citrobacter, Acinetobacter, Haemophilus influenzae (including β-lactamase producing strains) and Haemophilus parainfluenzae , Moraxella catarrhalis (including producing β-lactamase), etc.; Gram-positive cocci include Streptococcus pneumoniae (including penicillin-resistant bacteria), Streptococcus pyoge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04A61K31/431
Inventor 陈爱萍童明庆陆军姜东成葛育红沈飞
Owner NANJING YOKO PHARMA GRP CO LTD
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