Dihydromyricetin medicine treating acute and chronic bronchitis and its preparation method

A technology for dihydromyricetin and bronchitis, which is applied in the preparation of sugar derivatives, drug combinations, pharmaceutical formulations, etc., can solve the problems of lack of dihydromyricetin, inconvenience to carry, and high dosage of medicines, and achieves the treatment of acute and chronic diseases. Bronchitis, inhibit the deterioration of liver cells, safe and effective effect

Inactive Publication Date: 2012-11-14
GUIZHOU INST OF BIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For the treatment of acute and chronic bronchitis with traditional Chinese medicine, people have carried out more efforts, such as: Keke Tablets. From its characteristics, the current marketed drugs have the disadvantages of taking a lot of medicine and being inconvenient to carry. Therefore, , it is necessary to continue to develop new drugs for the treatment of acute and chronic bronchitis that are safe and reliable in efficacy
Dihydromyricetin, as a flavonoid compound widely present in Rutaceae fruits, can be used as a natural antioxidant in the food industry, and can also be used in the cosmetics industry, etc., but there is no dihydromyricetin that has the effect of treating acute and chronic Application report on bronchitis

Method used

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  • Dihydromyricetin medicine treating acute and chronic bronchitis and its preparation method
  • Dihydromyricetin medicine treating acute and chronic bronchitis and its preparation method
  • Dihydromyricetin medicine treating acute and chronic bronchitis and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Example 1. Antitussive pharmacological experiment of dihydromyricetin medicine

[0016] 1. Experimental animals: NIH mice, half male and half female, clean-grade standard, a total of 45 mice, sorted by body weight, selected healthy animals weighing 18-22 g, randomly divided into three groups, 15 mice in each group. Experimental groups such as negative control, positive control and dihydromyricetin drug samples were set up.

[0017] 2. Sample source and preparation:

[0018] (1) Dihydromyricetin sample group: an appropriate amount of dedihydromyricetin is fixed in a volumetric flask with normal saline, the concentration of dihydromyricetin is 2.0mg / ml, and the dihydromyricetin sample used is as described above Methods The dihydromyricetin monomer extracted from Chinese herbal medicines has a purity of over 95%.

[0019] (2) Methorphan: tablet, the content of methorphan is 15mg / tablet, take 2 tablets and dissolve in 20ml of normal saline to make a suspension, the concen...

Embodiment 2

[0033] Embodiment 2. The toxicology experiment of dihydromyricetin medicine

[0034] At a temperature of 24° C. and a humidity of 60±5%, 30 healthy clean-grade NIH mice were selected, half male and half female, weighing 18-22 g. The feed and water were disinfected, and the animals were raised under normal feed conditions before the test and during the observation period of the test.

[0035] Dihydromyricetin was dissolved in 0.5% Tween80 at a concentration of 900 mg / ml, and the liquid was orally administered to mice at a dosage of 0.2 ml / 20 g of mouse body weight. Observe 1, 4, 8, and 12 hours after administration, and observe every 12 hours thereafter. The death situation was observed, and the body weight change and other symptoms of the mice were recorded every day. On the 10th day, the mice were killed by neck dislocation, and the organs were taken for pathological examination.

[0036] On the 10th day, all the mice survived, and no toxic reaction was observed with 900 m...

Embodiment 3

[0037] Embodiment 3. Dihydromyricetin capsule preparation

[0038] Prepare gelatin capsules according to the following ingredient ratios

[0039] Dihydromyricetin 100

[0040] dry starch 40

[0041] Micronized silica gel 10

[0042] Mix the auxiliary materials and dihydromyricetin evenly, put them into transparent capsules, and get ready. Capacity: 150mg / capsule.

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Abstract

Belonging to the technical field of medicine processing, the invention relates to a dihydromyricetin medicine treating acute and chronic bronchitis and its preparation method. The medicine solves the problem of using dihydromyricetin to treat acute and chronic bronchitis, as well as cough with abundance of phlegm. And the medicine has the advantages of safety and effectiveness, small dosage, as well as no toxic and side effect. The extraction method of dihydromyricetin consists of: crushing a dihydromyricetin-containing medicinal material, conducting extraction at least one time, carrying out filtering, and combining the filtrate; concentrating the combined filtrate into an extract, which is subjected to alcohol precipitation and then applied on a column, or directly applying the extract on the column, performing column separation, and eluting an organic solvent; volatilizing the solvent of the eluting solution, thus obtaining a dihydromyricetin crude product; and then conducting recrystallization repeatedly to obtain a dihydromyricetin monomer, which is then synthesized by a chemical method, thus obtaining the dihydromyricetin medicine.

Description

technical field [0001] The invention relates to a dihydromyricetin medicine for treating acute and chronic bronchitis and a preparation method thereof, belonging to the technical field of medicine processing. Background technique [0002] Acute bronchitis is an acute inflammation of the bronchial tree mucosa caused by biological or abiotic pathogenic factors. Gas and other stimuli, allergic reactions to pollen and other people can also cause the disease. Exposure to cold, excessive fatigue, malnutrition and other factors lead to the decline of systemic resistance, or the local resistance of the bronchi is stimulated by unfavorable factors, which is often the cause of this disease. [0003] For the treatment of acute and chronic bronchitis with traditional Chinese medicine, people have carried out more efforts, such as: Keke Tablets. From its characteristics, the current marketed drugs have the disadvantages of taking a lot of medicine and being inconvenient to carry. Theref...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P11/00A61P11/14
Inventor 贾强罗文敏
Owner GUIZHOU INST OF BIOLOGY
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