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Azilsartan solid dispersion and preparation method and medicinal composition thereof

A technology of solid dispersion and composition, which is applied in the direction of drug combination, non-active ingredient medical preparations, pharmaceutical formulations, etc., can solve the problems such as the absorption and poor bioavailability of pharmaceutical active ingredients, and reduce pH dependence. , Improve solubility and good fluidity

Inactive Publication Date: 2012-11-28
JIANGSU HENGRUI MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This has adverse effects on the absorption and bioavailability of the active ingredients of the drug in the body

Method used

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  • Azilsartan solid dispersion and preparation method and medicinal composition thereof
  • Azilsartan solid dispersion and preparation method and medicinal composition thereof
  • Azilsartan solid dispersion and preparation method and medicinal composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 5g of azilsartan and 10g of povidone PVP-K30, add 400mL of methanol and stir until dissolved, transfer them to a vacuum drying oven, keep at 40°C, dry under reduced pressure for 24h, then pulverize, pass through a 60-mesh sieve, That is, azilsartan solid dispersion was obtained.

Embodiment 2

[0033] Weigh 5g of azilsartan and 15g of povidone PVP-K30, add 400mL of methanol and stir until dissolved, transfer them to a vacuum drying oven, keep at 40°C, dry under reduced pressure for 24 hours, then pulverize, pass through a 60-mesh sieve, That is, azilsartan solid dispersion was obtained.

Embodiment 3

[0035] Weigh 5g of azilsartan and 17.5g of povidone PVP-K30, add 400mL of methanol and stir until dissolved, transfer them to a vacuum drying oven, keep at 40°C, dry under reduced pressure for 24 hours, then pulverize and pass through a 60-mesh sieve , to obtain azilsartan solid dispersion.

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Abstract

The invention relates to an azilsartan solid dispersion and a preparation method and medicinal composition thereof. A solid dispersion system is prepared from azilsartan and pharmaceutically acceptable carrier materials of azilsartan. According to the invention, the problem of poor water solubility of asilsartan can be solved, the pH dependence of azilsartan dissolubility can be weakened, and azilsartan can achieve an ideal dissolving effect in different pH media.

Description

technical field [0001] The invention relates to an azilsartan solid dispersion, a preparation method thereof, a pharmaceutical composition containing it, and an application thereof in the preparation of antihypertensive drugs. . Background technique [0002] Drug products need to be effective and safe. In order to ensure the effectiveness and safety of pharmaceutical products, not only the effectiveness and safety of the active ingredient itself, but also the properties of the pharmaceutical preparation, such as the stability of the active ingredient in the preparation, the dissolution characteristics of the drug from the preparation, etc. are very important. For example, even if a preparation satisfies a certain level of quality immediately after preparation, if a medicinal ingredient in the preparation decomposes over time, the preparation is problematic in terms of effectiveness and safety of a pharmaceutical product. Regarding the dissolution characteristics of the dr...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/16A61K9/48A61K31/4245A61K47/38A61K47/34A61K47/32A61P9/12A61K47/10
Inventor 徐坚师帅郭晓峰杨闯石晓磊
Owner JIANGSU HENGRUI MEDICINE CO LTD
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