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Anti-obesity and anti-dyslipidemic effects of oil palm phenolics in preventing atherosclerosis and cardiovascular disease

An atherosclerosis and anti-lipidemia technology, which is applied in the field of anti-obesity and anti-dyslipidemia of oil palm phenolics in the prevention of atherosclerosis and cardiovascular diseases, and can solve problems other than prevention of atherosclerosis

Inactive Publication Date: 2012-12-12
MALASIAN PALM OIL BOARD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] However, most existing approaches are aimed at treating rather than preventing atherosclerosis

Method used

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  • Anti-obesity and anti-dyslipidemic effects of oil palm phenolics in preventing atherosclerosis and cardiovascular disease
  • Anti-obesity and anti-dyslipidemic effects of oil palm phenolics in preventing atherosclerosis and cardiovascular disease
  • Anti-obesity and anti-dyslipidemic effects of oil palm phenolics in preventing atherosclerosis and cardiovascular disease

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Experimental program
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Embodiment Construction

[0028]All male inbred immunodeficient mice (BALB / c mice) (n=40) specified in this study were purchased from the Medical Research Association in Kuala Lumpur, Malaysia, and the age of these male inbred BALB / c mice was approximately Five weeks after weaning. All animal procedures were approved by the Animal Care and Use Committee of the University of Malaya, Kuala Lumpur, Malaysia. Each animal was randomly assigned to a cage (n=5 / cage) and allowed to acclimate to the new environment for one week, during which distilled water and standard chow diet purchased from University of Malaysia were provided. At the start of the experiment, the animal's diet was changed to a custom-made, low-fat normal diet (58.2% kcal / kcal carbohydrate, 27.2% kcal / kcal protein and 14.6% kcal / kcal fat , which contains cellulose, a mineral mix, a vitamin mix, and racemic (DL-form) methionine), or change to a tailored, high-fat atherogenic diet (40.5% kcal / kcal of carbohydrates, 19.0 % kcal / kcal protein a...

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Abstract

Water-soluble phenolics from the oil palm (Elaeis guineensis) possess significant antioxidant and health-promoting properties. This invention documents the effects of administering oil palm phenolics to mice, with the aim of identifying whether these compounds possess significant anti-obesity or anti-dyslipidemics properties for the prevention of atherosclerosis and cardiovascular disease. We first explored the gene expression changes caused by oil palm phenolics in livers of mice given a low-fat normal diet, in which fatty acid beta oxidation genes were up-regulated while five cholesterol biosynthesis genes were down-regulated. In addition, the weight gain of mice given oil palm palm phenolics was delayed, suggesting that oil palm phenolics may play a role in delaying the onset of obesity. Using Illumina microarrays, we found that the atherogenic diet caused oxidative stress, up-regulated the inflammatory response and increased the turnover of metabolites and cells in the liver, spleen and heart. In contrast, we found that oil palm phenolics showed signs of attenuating the effects of the atherogenic diet in mice. The extract increased unfolded protein response in the liver, while attenuated antigen presentation and processing in the spleen. Oil palm phenolics also increased the expression of antioxidant genes in the heart. A majority of the genes regulated by oil palm phenolics in the different organs showed a difference in direction of regulation when compared to the atherogenic diet.

Description

technical field [0001] The present invention provides methods of delaying weight gain or obesity in animals, and preventing the dyslipidemic effects of an atherogenic diet in animals. The method comprises the step of supplying said animal with oil palm phenolics in drinking water. The aforementioned properties of oil palm phenolics are attributed to the upregulation of fatty acid beta oxidation and downregulation of cholesterol biosynthesis in the liver when the animals were fed a normal diet low in fat. In addition, when the animals were fed a high-fat, cholesterol-containing atherogenic diet, oil palm phenolics also upregulated the unfolded protein response in the liver and downregulated antigen presentation and antigen presentation in the spleen. processing, and upregulation of antioxidant genes in the heart. Therefore, for the prevention of atherosclerosis and cardiovascular diseases, oil palm phenolics can impart anti-inflammatory and antioxidant effects. Background t...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61P3/06A61K31/05A61P9/10
CPCA61K31/05A61K36/889A61P3/06A61P9/10
Inventor 拉维加德维·沙姆巴沙穆提谭友爱卡里亚纳·桑德拉姆·P.·马尼卡姆莫哈末·巴斯利·瓦西德
Owner MALASIAN PALM OIL BOARD
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