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Medicine composition of oral rehydration salt

A technology for rehydration salts and mixtures, applied in the field of medicine, can solve the problems of unqualified uniformity of finished products, agglomeration, and unsuitable dispersion of products.

Active Publication Date: 2014-03-12
西安安健药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of powder preparation and storage of finished products, various problems may be encountered, such as agglomeration and ball formation during the preparation process, which will affect drug packaging; agglomeration during storage may affect the dissolution of the drug during use
[0006] In addition, according to the traditional powder production method, the ingredients are crushed at one time and mixed in full, or the phenomenon of agglomeration and ball formation will occur more or less during the mixing process according to the general equal-volume incremental method, and the obtained product It is not suitable for dispersion, which affects the uniformity of mixing, and the next step of packaging cannot be carried out, and the uniformity of the finished product is not easy to pass
In addition, when our anhydrous glucose with the highest content is ground to a particle size of more than 80 mesh, such as 100 mesh and 120 mesh, and then mixed with other ingredients in various ways to make a finished product, it is found that when the finished product is dissolved in water before use, it will appear The phenomenon of crystallization and agglomeration, the dissolution of the product is slow, which seriously affects the use

Method used

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  • Medicine composition of oral rehydration salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] prescription: 375 parts by weight of potassium chloride, 650 parts by weight of sodium chloride, 725 parts by weight of sodium citrate, and 3375 parts by weight of glucose. The resulting composition can be denoted as R1, and the composition of the invention obtained hereinafter can be denoted similarly.

[0161] Preparation:

[0162] (1) Pulverizing the glucose into more than 80% of the glucose particle diameter is between 60 mesh and 80 mesh;

[0163] (2) Potassium chloride, sodium chloride, and sodium citrate are respectively pulverized into more than 80% of particle diameters between 80 mesh and 120 mesh;

[0164] (3) Get the potassium chloride powder of the recipe quantity that step (2) obtains, mix with the glucose powder that 1.5 times of weight step (1) pulverizes to obtain, and the degree of mixing reaches the [appearance uniformity] under the appendix powder of the second part of the Chinese Pharmacopoeia of the 2012 edition degree] inspection law require...

Embodiment 2

[0180] prescription: 1 part by weight of potassium chloride, 2.33 parts by weight of sodium chloride, 1.93 parts by weight of sodium citrate, and 13.3 parts by weight of glucose. The resulting composition of the invention may be designated R2.

[0181] Preparation: Carry out with reference to the method for embodiment 1, result:

[0182] (i) Agglomeration phenomenon: no agglomeration occurs in each mixing step;

[0183] (ii) mixing time: step (5) mixing required time 0.7h;

[0184] (iii) Dissolving time: the dissolving time is 85s.

Embodiment 3

[0186] prescription: 1 part by weight of potassium chloride, 2.4 parts by weight of sodium chloride, 1.6 parts by weight of sodium citrate, and 14 parts by weight of glucose.

[0187] Preparation: Carry out with reference to the method for embodiment 1, result:

[0188] (i) Agglomeration phenomenon: no agglomeration occurs in each mixing step;

[0189] (ii) mixing time: step (5) mixing required time 0.9h;

[0190] (iii) Dissolving time: the dissolving time is 90s.

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Abstract

The invention relates to a medicine composition of oral rehydration salt, which also can be called oral rehydration salt powder III in some embodiments. Specifically, the medicine composition of oral rehydration salt comprises potassium chloride, sodium chloride, sodium citrate and glucose. More specifically, the oral rehydration salt powder comprises 1 part of potassium chloride, 1.3-2.5 parts of sodium chloride, 1.5-2.5 parts of sodium citrate and 6-15 parts of glucose by weight. The oral rehydration salt powder provided by the invention has the characteristics that the preparation technology is simple, the process control is easy, the phenomena of crystallization and clustering are avoided in the preparation process, the product dissolution speed is high, and the like. The oral rehydration salt powder provided by the invention obviously overcomes some important technical problems often caused by the common powder, can provide an oral rehydration salt preparation with good pharmaceutical performance for clinical use, has significant innovation, and is certainly to bring tremendous social and economic benefits.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of powdered or granular oral rehydration salt powder, which can also be called oral rehydration salt powder III in some instances. This medicine contains dextrose along with sodium chloride, potassium chloride, sodium citrate. Background technique [0002] Salt is one of the indispensable ingredients in human life. According to Apalin (the world-renowned biochemist of the former Soviet Union, 1894-1980) in "The Origin of Life": "Humans and even all life are Derived and evolved from seawater, some life forms landed, while some life remained in the seawater." [0003] Originally human beings and all animals and plants on land originated from the ocean. To this day, no one disputes this theory. The sea is the mother of all life. Seawater contains a variety of minerals, and the minerals in seawater are also the minerals contained in the human body. Th...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P3/02A61K31/7004
Inventor 曾韶辉傅卫国王佩贤梅丹
Owner 西安安健药业有限公司
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