Green synthesis process of aryl methyl low-carbonate

Abstract

The invention belongs to the field of organic synthesis technique, and particularly relates to a green synthesis process of aryl methyl low-carbonate. The process is suitable for aryl low-carbonate, particularly for the synthesis of methyl esters of various non-steroidal anti-inflammatory drugs such as ibuprofen. The invention provides a universally applicable clean production process of aryl methyl carbonate. Through applying water absorption and polarity of glycerol and combining adoption of separation technique of simulated moving bed chromatography, the process simplifies treatment of reaction mixture, ensures complete separation of reaction product and the rest impurities such as surplus reaction raw materials, solves the problems of recycling of the surplus reaction raw materials, catalyst and water absorbent glycerol, can acquire product with high purity under the premises of water washing-free, no rectification and no three wastes, increases conversion rate of the raw material and yield of the product to be close to 100%, largely reduces production cost, achieves zero release of waste water and waste residue during the product production process, and has a broad application prospect in the fields of medicine, fine chemical industry and the like.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, in particular to a green synthesis process of aryl methyl subcarbonate. Background technique [0002] Aryl methyl subcarbonate is widely used in fine chemicals and is a very common type of flavor and fragrance. Some of them, such as methyl salicylate, are mainly used as fragrances for medicines; some, such as methyl phenylacetate, cinnamon Acetate methyl ester, etc., are food flavors and daily chemical flavors. [0003] At the same time, methyl aryl subcarbonate is also a class of important pharmaceutical intermediates, some of which, such as methyl salicylate and diclofenac methyl [1], can be used as raw materials by themselves, and some, such as ibuprofen methyl [ 2], which is an important intermediate for chiral resolution. Therefore, it is of great significance to study and improve the synthetic method of methyl aryl ethyl (propionate) to realize the greening and environmental fri...

AI Technical Summary

Problems solved by technology

[0004] Regarding the synthesis of aryl methyl subcarbonate, traditional chemical synthesis processes include acid chloride method, concentrated sulfuric acid catalysis method, alkali catalysis method, etc. These several processes all need to wash the product to neutrality with saturated salt water when recovering the product. Therefore, a large amount of high-COD and high-salt wastewater will be produced, which will not only cause corrosion of equipment, but also cause extremely serious pollution to the environment.

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