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Transdermally absorbed preparation of anti-dementia drug

A preparation and drug technology, applied in the field of percutaneous absorption preparations

Inactive Publication Date: 2014-07-23
TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014]However, when the administration period of the anti-dementia drug is set to about one week, the sticking area of ​​the preparation increases with the increase of the drug amount , the attachment position is limited, and the use of percutaneous absorption preparations often becomes difficult on the patient side

Method used

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  • Transdermally absorbed preparation of anti-dementia drug
  • Transdermally absorbed preparation of anti-dementia drug
  • Transdermally absorbed preparation of anti-dementia drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] [Table 1]

[0093]

[0094] The above plaster solution was coated on a polyethylene terephthalate liner, and dried at 70° C. for 15 minutes to obtain a drug-containing layer. Adjusted so that the amount of the dried drug-containing layer is 100 g / m 2 .

[0095] Then, the upper support layer (Scotchpak (商标) 9732, manufactured by 3M). Thereafter, the liner was peeled off from the drug-containing layer to obtain a laminate.

[0096] Fixture setting

[0097] Duro-Tak (商标) 87-2287 (manufactured by National Starch & Chemical) was coated on a polyethylene terephthalate liner, and dried at 80° C. for 15 minutes to obtain an adhesive layer. Make the quality of the adhesive layer after drying be 100g / m 2 . Then, an upper covering layer (polyester fabric) was laminated on one side of the adhesive layer opposite to the liner to obtain a fixing mechanism.

[0098] Next, the liner on the adhesive layer of the fixing means was peeled off, and the support layer of the pr...

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Abstract

The present invention relates to a transdermal preparation capable of stably administering an anti-dementia drug for a long period of about one week. More specifically, the present invention relates to a transdermal absorption preparation of an anti-dementia drug comprising a drug-containing layer containing an anti-dementia therapeutic drug, a polymer compound having an amino group, and a polyhydric alcohol fatty acid ester , polyols, polycarboxylates and styrenic polymers.

Description

[0001] References to related applications [0002] This patent application claims priority based on Japanese Patent Application No. 2009-285466 filed on December 16, 2009, and the entire disclosure content of said prior patent application is incorporated as a part of the disclosure of this specification. technical field [0003] The present invention relates to a transdermal absorption preparation capable of long-term and stable administration of anti-dementia drugs. Background technique [0004] In recent years, with the increase of elderly people, the number of patients with dementia such as Alzheimer's disease has also increased, and the care of patients has become a social issue. On the other hand, the development of anti-dementia drugs is also rapidly progressing. For example, donepezil hydrochloride is widely used as a therapeutic agent for Alzheimer's disease having an acetylcholinesterase inhibitory effect. In the past, these anti-dementia drugs were mostly admin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/13A61K31/27A61K31/445A61K31/473A61K31/55A61K47/10A61K47/14A61K47/32A61P25/28
CPCA61K47/14A61K47/26A61K9/7084A61K31/473A61K47/32A61K31/445A61K31/55A61K31/27A61K31/13A61K9/7053A61P25/28A61K9/70
Inventor 伊东健
Owner TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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