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Inhalant containing sodium 2-mercaptoethane sulfonate and ciclesonide and preparation method thereof

A technology of sodium mercaptosulfonate and ciclesonide, which is applied in the field of inhalation powder and its preparation, can solve problems such as local irritation and bronchospasm, and achieve improved airway remodeling, good therapeutic effect, and reduced The effect of serum IgE

Inactive Publication Date: 2013-01-02
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, it is used to eliminate phlegm and treat sodium mercaptosulfonate by atomization inhalation or tracheal instillation, 20% solution 1 ~ 2ml, but there is irritation, and it is easy to cause local irritation when using sodium mercaptosulfonate for treatment Effect, can cause cough, bronchospasm and other adverse reactions

Method used

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  • Inhalant containing sodium 2-mercaptoethane sulfonate and ciclesonide and preparation method thereof
  • Inhalant containing sodium 2-mercaptoethane sulfonate and ciclesonide and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] Dissolve 80 mg of ciclesonide and 1 g of sodium mercaptosulfonate in ethanol. After filtration, the filtrate is spray-dried and micronized so that the average particle size reaches 2 μm. 10 g of lactose is micronized by a fluid energy mill to an average particle size of 20 μm. After mixing, pass through a 200-mesh sieve for 3 times and mix evenly, then pack into No. 3 capsules. Each capsule contains ciclesonide 80μg, sodium mercaptosulfonate 1mg

[0037] The process conditions are: the inlet temperature is 105°C, the outlet temperature is 68°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2-1

[0039] Dissolve 250 mg of ciclesonide and 2,500 mg of sodium mercaptosulfonate in ethanol. After filtration, the filtrate is spray-dried and micronized so that the average particle size reaches 4 μm. Lactose 40 g is micronized by a fluid energy mill to an average particle size of 30 μm. Mix evenly, mix evenly with a 200-mesh sieve for 3 times, and distribute into No. 3 capsules. Each capsule contains ciclesonide 80μg, sodium mercaptosulfonate 2.5mg

[0040] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 68°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

Embodiment 2-2

[0042] According to the formulation of Example 2-1, the carrier was changed to octaacetate-D-cellobiose octaacetate with an average particle size of 35 μm, and the powder spray was prepared according to the process of Example 2-1.

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Abstract

The invention relates to an inhalant containing sodium 2-mercaptoethane sulfonate and ciclesonide and preparation method thereof. The inhalant is composed of ciclesonide and sodium 2-mercaptoethane sulfonate as the active ingredients, and one or more pharmaceutical adjuvants suitable for inhalation drug delivery.

Description

Technical field: [0001] The invention relates to a medicine for treating respiratory diseases, especially asthma, in particular to an inhalation powder spray and a preparation method thereof. Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma symptoms be achieved. At present, the drugs for the treatment of asthma and other lung diseases mainly include the following: (1) β2-receptor agonists, (2) xanthine drugs, (3) anti...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/185A61K9/72A61P11/06
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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