27 results about "Inhalation drugs" patented technology

The invention aims to provide a preparation method and application of an inhalation drug-loading ultrasonic driving nano motor, and can effectively solve the problems of preparation of the inhalation drug-loading ultrasonic driving nano motor and application of the inhalation drug-loading ultrasonic driving nano motor in preparation of drugs for treating IPF. Comprising the following steps: firstly preparing PLGA-PFD nanoparticles, then preparing PDA-PLGA-PFD nanoparticles, and finally preparing BNN6 / PDA-PLGA-PFD, namely the asymmetric nano motor BPPP with the ultrasonic responsiveness. The product disclosed by the invention is scientific and advanced in preparation method, good in product performance, high in atomization administration and IPF lung pathological barrier penetrating capability, high in medicine utilization rate, good in curative effect, simple and convenient to operate, wide in application prospect and huge in economic and social benefits.

The invention discloses an inhalation administration device and a design method, and mainly relates to the technical field of medical instruments. The device comprises a capsule base, a capsule body, a capsule cabin and a suction nozzle, an inner cavity of the suction nozzle is of an inverted trapezoid structure, and in other words, the diameter of the section is increased by 0.033 mm every time the inner area of the suction nozzle is raised by 1 mm from the bottom end to the top end. According to the design, by optimizing the internal flow field of the suction nozzle, the dispersity of medicine particles can be remarkably improved, wall surface deposition is reduced, and therefore the dispersity of the medicine particles and the lung deposition efficiency are improved. The invention also provides a design method based on lattice Boltzmann method-immersion boundary method-large eddy simulation multi-physics field coupling numerical simulation, and by setting specific performance evaluation parameters, the structure optimization of the inverted trapezoidal suction nozzle can be efficiently and accurately guided. An in-vitro deposition test shows that the performance of the device is superior to or equivalent to that of a commercially available product.

The invention discloses a multi-substituted cyclodextrin supramolecular material as well as a preparation method and application thereof and a pharmaceutical composition, and relates to the technical field of supramolecular materials, and the multi-substituted cyclodextrin supramolecular material is obtained by coordination of multi-substituted cyclodextrin and metal ions. The CD-pMOF prepared by the preparation method disclosed by the invention has relatively strong drug loading capacity, and shows an excellent protective effect on unstable drugs; and the prepared CD-pMOFs with different sizes respectively have relatively good upper respiratory tract and lung deposition effects, and have wide application prospects in inhalation drug delivery systems.

The utility model provides a mouse nasal inhalation drug delivery system, and belongs to the technical field of animal experiment instruments. The mouse nasal inhalation administration system comprises a fixing device used for placing and fixing a mouse; the mouse oral cavity closing device is arranged on the fixing device and is used for binding and closing the oral cavity of the mouse on the fixing device; the drug delivery channel clamping device is arranged on the fixing device and used for clamping and fixing the drug delivery channel, and when the mouse is fixed to the fixing device and the drug delivery channel is clamped and fixed to the drug delivery channel clamping device, a liquid medicine outlet of the drug delivery channel is located over the nasal cavity of the mouse. The mouse nasal inhalation drug delivery system can fix a mouse, liberate the hands of experimenters for fixing the mouse, close the oral cavity of the mouse, reduce drug loss, improve drug delivery precision and increase experiment accuracy.

The present disclosure provides an inhalation drug auxiliary device, and relates to the technical field of medical devices, which solves the technical problem of requiring a large force to press the puncture part of an inhaler to break a capsule. The inhalation drug auxiliary device comprises a shell and an automatic breaking module, the shell is arranged outside the inhaler to fix the inhaler, and the automatic breaking module is arranged on the shell to automatically break the capsule placed in the inhaler. The automatic breaking module arranged on the shell automatically breaks the capsule in the inhaler, solving the technical problem of requiring a large force to press the puncture part of the inhaler to break the capsule, and the weak users have difficulty in pressing, which is not friendly to the old and young users.

The invention discloses an AI-based intelligent monitoring and reminding system and method for medicine inhaled for children asthma, and relates to the technical field of intelligent medical monitoring and AI application, the system comprises the following components: an intelligent monitoring terminal, an AI analysis platform, a multi-terminal reminding module and a medical cooperation terminal; through the intelligent monitoring terminal integrated on the asthma inhalation medicine container, various operation data and environment data in the medicine taking process of children can be accurately collected in real time, and the data are deeply processed and analyzed through the AI analysis platform; the system can accurately evaluate the medication operation standardization, the actual inhalation dose deviation and the medication compliance level of children, the system sends out a prompt signal at the preset medication time through the multi-terminal reminding module, and immediately sends out a warning signal when the operation is not standard, the dose is out of tolerance or the health risk exceeds the standard, so that the medication compliance of the children is effectively improved, and the medication compliance of the children is improved. And the medicine can be correctly inhaled on time according to the quantity, so that the treatment effect is improved.

The utility model provides a portable aerosol mouth-nose inhalation administration device. The portable aerosol mouth-nose inhalation administration device comprises a main body and a container attached to the main body, the container is internally provided with a containing cavity used for containing liquid medicine and provided with an injection port used for injecting the liquid medicine; the atomizer is arranged in the containing cavity and used for atomizing the liquid medicine to generate aerosol; wherein most of the area of the container is configured to be in an exposed state, and the exposed part of the container is configured to be transparent so that a user can observe the state of the liquid medicine and the state of the atomizer in the containing cavity. According to the portable aerosol mouth-nose inhalation administration device, most of the container is exposed, the visual effect is good, a user can conveniently observe the state of liquid medicine and the state of the atomizer, the whole aerosol mouth-nose inhalation administration device is in a flat oval cone shape, the mist outlet nozzle is designed to be delicious in inhalation and capable of being snorted, and the portable aerosol mouth-nose inhalation administration device is small, exquisite, good in hand feeling and convenient to use.

A head model (1) for testing of inhalation drugs, said head model (1) comprising a model mouth (5)with a mouth opening (5a), a model nose (9) with two nose openings (9a) and a model trachea (13) reaching from a trachea first end (13a) to a trachea second end (13b), wherein said trachea first end (13a) is configured for connection to an external device. Said head model further comprising an anatomically realistic nose flow path (15) fluidly connected to the trachea second end (13b) and reaching between the nose openings (9a) and the trachea second (end (13b) and an anatomically realistic mouth flow path (19) fluidly connected to the trachea second end (13b) and reaching between the mouth opening (5a) and the trachea second end (13b). Siad head model further comprising an adjustable restrictor (21) positioned in connection with the nose flow path (15) and arranged such that it can be adjusted to allow different amounts of flow through the nose flow path (15).

An animal restraint device for inhalation drug administration comprises: a support frame consisting of multiple support legs and support plates at the top of the support legs; an animal restraint box mounted on the support plates for accommodating and restraining experimental animals; a head cover with a side opening closable to one side of the animal restraint box along its length; and a tray movably mounted on the support legs and located below the animal restraint box, the tray having sliding through holes corresponding to the support legs, the tray being slidably connected to the support legs through the sliding through holes; a support hole communicating with the sliding through hole and a fixing member disposed within the support hole on the side of the tray; a predetermined gap exists between the sliding through hole of the tray and the support leg to allow adjustment of the tray's horizontal angle by adjusting only the height of one side of the tray. This device can reduce pressure on the lungs and abdomen of large animals, improving the accuracy and stability of inhalation drug administration data for large animals.

The present application relates to a kind of biomimetic lung surfactant carrier, which is prepared from total fat and simulation peptide, in the total fat, the mass ratio of dipalmitoyl phosphatidylcholine, dipalmitoyl phosphatidylglycerol, dipalmitoyl phosphatidyl ethanolamine-polyethylene glycol 2000, cholesterol is 8-12:1:1:1;The lung surfactant simulation peptide is the simulation peptide of SP-B protein and / or the simulation peptide of SP-C protein.The biomimetic lung surfactant carrier has the advantages of high loading rate and high stability.The present application also relates to inhalation dosage form of drug for treating pulmonary arterial hypertension loaded by the biomimetic lung surfactant carrier, which makes the loaded drug obtain more uniform intra-pulmonary distribution, the inhalation drug is more close to natural lung surfactant in composition and physiological function, can delay the degradation of product, improve the utilization rate of drug, achieve good pulmonary arterial hypertension treatment effect.

The invention relates to the technical field of drug delivery devices, and discloses a suction type drug delivery device which comprises a capsule for storing dry powder and further comprises a partition plate fixedly arranged in the capsule and dividing the internal space of the capsule into an upper storage cavity and a lower storage cavity; a moving groove for allowing the capsule to pass through is transversely formed in the shell in a penetrating manner; the upper tool bit and the lower tool bit are fixedly mounted at the top and the bottom of the moving groove respectively, and when the capsule passes through the moving groove, the upper tool bit and the lower tool bit are used for cutting off the top end and the bottom end of the capsule respectively. A partition plate is arranged in the capsule, different types of medicines can be effectively separated, independence of the medicines during storage is ensured, mutual reaction is prevented, the two medicines can be released according to a preset proportion during inhalation, and personalized treatment requirements are met. When a patient inhales the medicine, two different types of medicine released from the capsule can be instantly mixed in the mixing tube, so that the medicine inhaled by the patient is uniform, and the treatment effect is remarkably improved.

1. Name of the product in this design: Inhalation drug monitoring device. 2. Purpose of this design: To monitor the administration of inhaled medications. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention provides a medication application device and an inhalation medication application system, which relates to the field of medical appliances and solves the problem that the medication application operation of the inhalation medication device is cumbersome and inconvenient to use. The medication application device includes a shell, a driving mechanism and a fixed seat located in the shell. The shell is used to accommodate the inhalation medication device, and the two are detachably connected. The shell allows the suction nozzle of the inhalation medication device to extend; the fixed seat is positioned and connected to the rotating base of the inhalation medication device. After the fixed seat and the rotating base are connected in place, the two can rotate synchronously; the driving mechanism is transmission-connected to the fixed seat, and is used to drive the fixed seat to rotate, thereby driving the rotating base to rotate, and then completing the medication application. The driving mechanism in the shell drives the fixed seat to rotate, thereby driving the rotating base to rotate to the left or right, and then completing the medication application of the inhalation medication device. There is no need to manually rotate the rotating base, which assists the patient in completing the medication application operation, and is easy to use.

1. The name of this design product: Inhalation drug delivery device. 2. Purpose of this design product: This design product is a medical device used for oral inhalation medication. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

This invention discloses a lyophilized exosome formulation of Liubao tea with low nebulization loss rate, its preparation method, and its application, relating to the fields of biomedicine and inhalation formulation technology. The active ingredient is Liubao tea exosomes, and it also contains a pharmaceutically acceptable lyophilization protectant. The lyophilized formulation, after reconstitution, is adapted to a mesh nebulizer for nebulization inhalation. The Liubao tea exosomes are extracted by the following method: Liubao tea leaves are washed, rapidly frozen and ground in liquid nitrogen, homogenized with buffer solution, and allowed to stand at low temperature. Then, they are subjected to gradient centrifugation, filtration clarification, and purification and enrichment using a microfluidic chip system. The microfluidic chip system is the Huixin Bio EXODUS fully automated exosome extraction system, which relies on sonication and eddy current coupling physical fields to achieve selective separation of exosomes. This invention prepares Liubao tea exosomes into a lyophilized formulation specifically for nebulization inhalation, expanding the application direction of exosomes from fermented tea plants in the field of respiratory inhalation drug delivery.

1. Name of the product in this design: Inhaler. 2. Purpose of this design: for nebulized inhalation drug delivery. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Design 1 is designated as the basic design.

The invention discloses an inhalation type drug delivery system with a phospholipid-protein surface active structure and application of the inhalation type drug delivery system. The inhalation type drug delivery system comprises liposome vesicles modified by PEG (polyethylene glycol)-angiotensin converting enzyme II substrate polypeptide, and alveolar surface active substances are loaded in the liposome vesicles. According to the inhalation type drug delivery system, the drug can be delivered into the lung in an aerosol inhalation mode and can be evenly distributed in pulmonary alveoli, pulmonary alveoli development can be effectively promoted, the ventilation function can be improved, and the inhalation type drug delivery system has a good curative effect in premature infant pulmonary dysplasia treatment. According to the inhalation type pulmonary alveolar surface active substance delivery system, an existing administration mode that liquid drops are dropped through a trachea cannula is changed, and the problems that segmental pulmonary atelectasis, asphyxia and the like are possibly caused are solved. The inhalation type drug delivery system can be stably and efficiently degraded when reaching the pulmonary alveoli, and is safe and low in toxicity.

The invention belongs to the technical field of medical instruments, and discloses an inhalation administration device for respiration and critically ill medical departments, which comprises an administration bottle body and a medicine storage bottle body, the medicine storage bottle body contains liquid medicine required by inhalation administration, the administration bottle body is connected with a mask, a pressurizing assembly and a liquid drawing assembly, the pressurizing assembly comprises a box body and a driving part, and the driving part is connected with the box body. A pressurizing cavity is formed in the inner side of the box body, a pair of pressurizing gears are connected to the inner side of the pressurizing cavity, the liquid drawing assembly comprises a liquid drawing barrel and atomization equipment, the liquid drawing barrel is connected with a piston and a spring, and the mask communicates with a medicine guide pipe and an expiration pipe. The pressurizing assembly is used for pressurizing gas exhaled by a patient, the liquid drawing assembly is used for drawing liquid medicine needed by inhalation and administration, during expiration, the piston exhausts gas in the liquid drawing barrel, during inhalation, the piston moves reversely under the action of the spring to draw the liquid medicine, administration is achieved through the medicine guide pipe, the administration efficiency is high, and the administration effect is good.

The invention discloses an inhalation administration device, and relates to the technical field of medical auxiliary instruments. In order to solve the problems that an existing inhalation drug delivery device cannot monitor the real-time breathing state of a patient, drug waste is easily caused, and necessary safety is lacked, the inhalation drug delivery device comprises a mask, an atomizer and a breathing monitoring assembly, the atomizer is connected with the mask through a drug delivery pipeline, and the atomizer is connected with the mask through a drug delivery pipeline. The breathing monitoring assembly is connected with the mask through a breathing pipeline, and a control valve assembly is further arranged between the breathing monitoring assembly and the atomizer and used for blocking connection between the atomizer and the mask when a patient exhales; the respiration monitoring assembly can be adjusted in a self-adaptive mode according to the expiration intensity of the patient, and the expired gas is exhausted at different speeds. The breathing of a patient can be dynamically monitored, medicine waste can be avoided, and the use safety of the device is improved through the arrangement of self-use exhaust.

The utility model relates to the field of medical instruments, in particular to a bracelet type snorting drug delivery device which comprises an annular belt, a drug cabin, a drug delivery hole, an opening and closing mechanism and a drug inlet. The two ends of the medicine cabin are movably connected with the two ends of the annular belt respectively, the medicine cabin is communicated with the atmosphere through the medicine feeding hole, and the opening and closing mechanism is connected with the medicine cabin in a sleeved mode and movably connected with the medicine feeding hole. The medicine cabin comprises a medicine storage cabin and two end cabins, the two end cabins are detachably connected with the two ends of the medicine storage cabin respectively, and the medicine inlet is formed in the middle of the medicine cabin and used for injecting medicine; when the medicine is liquid medicine, an atomization system, a timing system and a flow monitoring system are additionally arranged, the atomization system, the timing system and the flow monitoring system are integrated into the end cabin, the flow monitoring system is electrically connected with the atomization system, and a flow velocity sensor can monitor the medicine atomization flow in real time and feed the medicine atomization flow back to the atomization system. The accuracy of the dosage is further guaranteed, and the treatment process is more scientific and reliable.

The present disclosure relates to a spray inhalation drug dose estimate calculation and real-time medication guidance system using turbidity imaging and deep learning, and a control method thereof. The system captures an image of a drug that is not properly inhaled by a patient and is not administered into the body but disappears cloudily into the air, estimates an inhalation drug dose by performing deep learning on the turbidity of the captured image, and provides feedback to notify a user, so that the user can easily determine the inhalation drug dose among all drugs, thereby improving user convenience.

The present invention discloses a portable active inhalation drug delivery device based on MEMS, comprising: a liquid medicine box, an oil guide plate, a porous oil guide member, an atomization chip, a base, a PCB board and a suction nozzle, a liquid medicine guide port is provided at the bottom of the liquid medicine box, a symmetrically arranged air intake through hole is provided on one opposite side wall of the liquid medicine box, an air intake groove is provided on the oil guide plate, two air intake through holes are symmetrically arranged at both ends of the air intake groove, the porous oil guide member is fixedly mounted on the back of the oil guide plate, the atomization chip is fixedly mounted on the mounting seat of the base, the PCB board is fixedly mounted on the back of the base, a first aerosol channel is provided in the mounting seat, a metal electrode is provided on the mounting seat, the suction nozzle is fixedly mounted on the base, and a second aerosol channel is provided in the suction nozzle. Compared with the prior art, the present invention has uniform atomization of liquid medicine, a high proportion of liquid medicine particles with a target diameter, and active inhalation drug delivery, which effectively controls the dosage and prevents choking and coughing.

The present invention discloses a drug delivery device for inhalation drugs, which belongs to the technical field of medical devices, and comprises a box body; a suction nozzle is provided on the upper side of the box body; a rotating frame is rotatably installed on the left side of the box body, and a protective cover is fixedly installed on the upper side of the rotating frame; a tongue depressor assembly is installed on the suction nozzle; the protective cover is snap-connected with the suction nozzle; a floating drug storage assembly is installed inside the box body; a fan is installed in the floating drug storage assembly; a drug delivery assembly, a first locking assembly, and a second locking assembly are installed inside the box body, the lower end of the rotating frame, and the lower end of the tongue depressor assembly; the outlet of the drug delivery assembly is connected to the suction nozzle; the atomization outlet of the fan is fixedly connected to the lower end of the conveying pipe, the upper end of the conveying pipe passes through the floating drug storage assembly and is fixedly connected to one end of a hose, and the other end of the hose is fixedly connected to the upper end of the drug delivery assembly. Through the above-mentioned method, the medicine powder is shaken evenly before atomization, the tongue depressor assembly pushes the user's tongue backward, and the medicine delivery assembly pushes the atomized medicine to accelerate the flow into the user's mouth.

The invention discloses inhalation type quercetin dry powder inhalation and a preparation method thereof, and belongs to the technical field of inhalation administration. Aiming at the problems of low oral bioavailability, poor targeting property and the like of quercetin, the dry powder inhalation is prepared from the following components in percentage by weight: 10 to 100 percent of quercetin, 0 to 85 percent of diluent and 0 to 5 percent of taste indicator, and the particle size of quercetin particles is D90lt; 20 [mu] m. The preparation method comprises the following steps: crushing the quercetin and the diluent, mixing with the taste indicator, sieving, spheroidizing in a spheroidizing disc to prepare spherical particles, and finally filling into an inhaler. The dry powder aerosol realizes lung targeted delivery through inhalation administration, has good fluidity and lung deposition effect, is mainly used for treating lung nodules, and provides an efficient and safe treatment scheme for lung diseases.

Provided herein are pharmaceutical formulations of Compound A or a pharmaceutically acceptable salt thereof for inhalation. Also provided are methods of making and using pharmaceutical formulations of Compound A for inhalation for the treatment of a disease or condition, such as idiopathic pulmonary fibrosis.

The invention relates to atomization auxiliary equipment and an atomization system, and belongs to the technical field of atomization treatment. The atomization auxiliary device comprises an auxiliary respirator and an information processing module, and can be used in cooperation with an inhalation drug delivery module for providing drugs applied to the respiratory tract of a patient according to an atomization mode, so that an atomization system is formed. The information processing module obtains the breathing frequency of the patient based on the time sequence data of the breathing sound collected by the breathing sound collecting unit, and determines the starting time of the inflatable clothes according to the matching condition of the breathing frequency of the patient and the medicine supply frequency of the inhalation medicine supply module; on the basis of correlation analysis of breathing sound / lung sound signals collected by the auxiliary respirator and medicine flow data, the information processing module generates adjusting instructions about the atomization position, the breathing mode and / or the atomization medicine proportion. The breathing state of the patient in the atomization process is judged according to the breathing sound / lung sound signals, and the effect of the patient in the atomization process is obtained in real time according to the breathing state.

The present invention discloses an inhalation administration device, comprising a pressure propeller, a first housing and a second housing; the first housing is connected to the second housing to form an accommodation space, and the pressure propeller is arranged in the accommodation space; the pressure propeller comprises a pressure accumulation mechanism and a release mechanism; the pressure accumulation mechanism has two states of pressure accumulation and release. In the pressure accumulation state, the pressure accumulation mechanism is engaged with the release mechanism; in the release state, the pressure accumulation mechanism is disengaged from the release mechanism; when the pressure inside the inhalation administration device is less than the external pressure, the atmospheric pressure drives the release mechanism to release the pressure accumulation mechanism. The inhalation administration device of the present invention has a pressure accumulation mechanism and a release mechanism. After the pressure accumulation mechanism accumulates pressure, it is released by the release mechanism. The release action of the release mechanism is triggered by the user's inhalation, completely separating the user's hand operation from the breathing rhythm, and perfectly realizing the synchronization of drug ejection and the user's inhalation.