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Method for extracting kavalactones by using subcritical water

A kava lactone and subcritical water technology, applied in the biological field, can solve problems such as low efficiency, and achieve the effect of low operating cost and large production capacity

Inactive Publication Date: 2013-01-09
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the domestic extraction methods for the effective components of kava generally use normal temperature and normal pressure extraction, which is inefficient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Crush the root of Kava pepper, take 5kg, put it into a subcritical extraction kettle, pass it into deionized water, and extract it dynamically for 50min at a temperature of 120°C and a pressure of 0.5MPa, and add the extract to an AB-8 macroporous resin column for adsorption , first take 4BV30% ethanol solution to elute impurities, then use 4BV80% ethanol solution to elute, collect the eluate and concentrate under reduced pressure, extract the concentrated solution with ethyl acetate for 3 times, collect the ethyl acetate solution, concentrate and dry to obtain white kavalactone , content 95%, yield 85%.

Embodiment 2

[0017] Crush the root of Kava pepper, take 5kg, put it into a subcritical extraction kettle, pass it into deionized water, and extract it dynamically for 40min at a temperature of 140°C and a pressure of 0.6MPa. 3BV20% ethanol solution to elute impurities, and then 5BV70% ethanol solution to elute, collect the eluate and concentrate under reduced pressure, extract the concentrated solution with ethyl acetate for 3 times, collect the ethyl acetate solution, concentrate and dry to obtain white kavalactone, the content 93%, yield 76%.

Embodiment 3

[0019] Crush the root of Kava pepper, take 5kg, put it into a subcritical extraction kettle, pass it into deionized water, and extract it dynamically for 30min at a temperature of 160°C and a pressure of 1MPa, and add the extract to the ADS-21 macroporous resin column for adsorption. First take 3BV30% ethanol solution to elute the impurities, then use 3BV85% ethanol solution to elute, collect the eluate and concentrate under reduced pressure, extract the concentrated solution with ethyl acetate three times, collect the ethyl acetate solution, concentrate and dry to obtain white kavalactone, Content 92.3%, yield 76%.

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PUM

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Abstract

The invention discloses a method for extracting kavalactones by using subcritical water. The method comprises the steps of grinding the roots of Piper methysticum Forst and then adding into a supercritical extraction kettle, feeding deionized water, dynamically extracting for 30 to 60 min under the conditions that the temperature is 110 to 180 DEG C and the pressure is 0.3 to 2 MPa, adding an extracting solution into a macroporous resin for absorption, gradiently eluting with ethanol solution, concentrating an eluent under reduced pressure, extracting a concentrated solution with ethyl acetate for 2 to 3 times, collecting an ethyl acetate layer for concentration, and drying to obtain a product. With the adoption of the method for production, the method is friendly to environment, industrial operation is easily implemented, the extraction efficiency is high, and the production period is short.

Description

technical field [0001] The invention belongs to the field of biological technology, in particular to a method for extracting kavalactone with subcritical water. Background technique [0002] Subcritical extraction is to use subcritical fluid as the extraction agent. In a closed, oxygen-free, high-pressure pressure vessel, according to the principle of similar solubility of organic matter, through the molecular diffusion process of the extraction material and the extraction agent during the soaking process, the solid material is obtained. It is a new extraction and separation technology that transfers the fat-soluble components in the liquid to the liquid extractant, and then separates the extractant from the target product through the process of vacuum evaporation, and finally obtains the target product. Compared with other separation methods, subcritical fluid extraction has many advantages. It can keep the active product of the extract without damage or oxidation. It has l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A61K31/366A61P25/22A61P25/20A61P21/02A61P23/02A61P29/00A61P31/04A61K125/00
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV
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