Paclitaxel lipid nanoparticle injection liquid with anti-tumor activity

A technology of lipid nanoparticles and anti-tumor activity, which is applied in anti-tumor drugs, liquid delivery, emulsion delivery, etc. It can solve the problem of drug resistance of tumor cells to chemotherapeutic drugs, limit SLN drug loading capacity, and multiple drug release curves Changes and other issues to achieve the effect of overcoming tumor drug resistance, excellent tumor drug resistance, and avoiding allergic reactions or toxic reactions
CN102871963AInactive Publication Date: 2013-01-16ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2013-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides paclitaxel lipid nanoparticle injection liquid, which comprises paclitaxel medicine, lipid materials, water for injection, surfactant, stabilizers and metal ion chelating agents. Most medicine is wrapped inside lipid, the direct contact between the medicine and blood or other liquid is avoided, and the local irritation of the medicine on the injection position is reduced, and the toxicity is reduced. No any organic solvents are contained, no solvents with toxicity and irritation on human bodies are contained, and no irritation and no sensitization are caused on the human bodies. The adverse reaction of the existing preparation caused by the recipe problem can be eliminated, and the goals of safety and efficiency are reached. Meanwhile, the paclitaxel lipid nanoparticle injection liquid has the excellent characteristic that the tumor medicine resistance is overcome, and the cure efficiency of the paclitaxel on the existing various tumors is greatly improved.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, and relates to a paclitaxel lipid nanoparticle injection, in particular to a preparation method of a novel lipid nanoparticle preparation containing paclitaxel and vitamin E, which has high-efficiency antitumor activity and overcomes tumor drug resistance. Background technique

[0002] Paclitaxel is a natural compound isolated from this slow-growing evergreen tree of the Taxus family. It has obvious and unique anti-tumor curative effect. Paclitaxel blocks mitosis by acting on intracellular tubulin, resulting in the death of rapidly dividing cancer cells. At the same time, paclitaxel can induce apoptosis, regulate immunity, and kill or inhibit tumor cells. The powerful and unique anti-tumor mechanism has made paclitaxel the most popular, best-selling, most scarce, most expensive, and also the most widely used anti-tumor drug in the world today. Paclitaxel is currently mainly applicable to ovarian cancer...

Claims

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