Application of Houttuynoid E in anti-human fungal drugs

An antifungal and drug technology applied in the field of Houttuynoid E, can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc., and achieve the effect of outstanding substantive characteristics and strong inhibitory activity against human fungi

Active Publication Date: 2013-06-19
南通三聚知识产权服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Houttuynoid E in anti-human fungal drugs
  • Application of Houttuynoid E in anti-human fungal drugs
  • Application of Houttuynoid E in anti-human fungal drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound Houttuynoid E tablet involved in the present invention:

[0014] Take 20 grams of compound Houttuynoid E, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0015] Embodiment 2: the preparation of compound Houttuynoid E capsule involved in the present invention:

[0016] Get 20 grams of compound Houttuynoid E, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0018] Experimental example: Anti-fungal activity of Houttuynoid E in humans

[0019] Anti-human fungus activity experiment is the method of concentration dilution, each determination is repeated three times, the test pathogens include Trichomonas rubrum, Microsporum lanoides and Phytophthora clematis, and the concentration of the bacterial solution is 10 5 individual / mL. The initial concentration of Houttuynoid E is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the same volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungal culture temperature 28 ℃ respectively, observe after 24 hours of incubation time, if no colony is found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Houttuynoid E against human fungi are shown in Table 1.

[0020] Table 1 Houttuynoid E anti-human fungal...

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Abstract

The invention relates to application of Houttuynoid E in preparing anti-human fungal drugs, belonging to the field of medicine. Houttuynoid E has strong effect of suppressing trichophyton rubrum, microsporum lanosum or trichophyton tonsurans; therefore, Houttuynoid E can be taken as an anti-human fungal compound and is expected to be applied to preparing related drugs. The use of Houttuynoid E inpreparing the anti-human fungal drugs involved in the invention is disclosed for the first time; as the framework type of Houttuynoid E is a brand new framework type and Houttuynoid E has an unexpectedly high inhibition activity for the human fungus without possibility of giving any implication by other compounds, Houttuynoid E has outstanding substantive features; and simultaneously, the application of Houttuynoid E for preventing and treating the human fungus apparently has obvious progress.

Description

technical field [0001] The invention relates to the application of Houttuynoid E, in particular to the application of Houttuynoid E in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Houttuynoid E involved in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P31/10
Inventor 黄蓉蒋鹤松吴俊华
Owner 南通三聚知识产权服务有限公司
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