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Frankincense rheumatism aerosol for curing rheumatism bone ache and preparation method thereof

A technology for rheumatic bone pain and rheumatic qi, which is applied in aerosol delivery, non-central analgesics, anti-inflammatory agents, etc., can solve the problems of poor uniformity, adverse reactions and harsh storage conditions of ordinary aerosols, and achieves Effects of skin irritation and allergy

Active Publication Date: 2013-01-16
广东同德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the adverse reactions brought by the current plaster and the harshness of storage conditions, and at the same time overcome the defects of poor uniformity of common aerosols, adopt microemulsion technology, because the microemulsion liquid has strong adhesion and permeability to the skin , so the therapeutic effect is obviously better than ointment and common aerosol

Method used

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  • Frankincense rheumatism aerosol for curing rheumatism bone ache and preparation method thereof
  • Frankincense rheumatism aerosol for curing rheumatism bone ache and preparation method thereof
  • Frankincense rheumatism aerosol for curing rheumatism bone ache and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Preparation:

[0029] ①Weigh 5g of frankincense, 5g of myrrh, and 0.25g of dried blood according to the prescription, crush them through an 80-mesh sieve, use 50g of oil phase, extract at 60°C for 48 hours, filter to obtain liquid A, and set aside;

[0030] ② Weigh artificial musk according to the prescription amount and grind it into fine powder (120 mesh sieve) 0.02g, add 5g of oil phase, stir and extract for 48 hours to obtain B liquid, set aside;

[0031] ③Put A and B into a colloidal ball mill for grinding and high-pressure homogenization to obtain 80-100nm C liquid;

[0032] ④ Mixing of penetration enhancer: mix and grind borneol and peppermint oil to form an oily co-dissolve, add laurocapram and muscone, add 12g of oil phase, stir to dissolve the oil, add C solution and mix evenly to obtain D solution, and set aside;

[0033] ⑤ Weigh 0.5 g of monoglyceride stearate and 0.2 g of 1,2-propanediol according to the prescription amount, add ionized water t...

Embodiment 2

[0037]

[0038] Preparation:

[0039] Referring to Example 1 preparation method.

Embodiment 3

[0041]

[0042] Preparation:

[0043] Referring to Example 1 preparation method.

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Abstract

The invention relates to a traditional Chinese medicine micro emulsion aerosol for curing rheumatism bone ache, in particular to a micro emulsion aerosol administration preparation. The aerosol comprises traditional Chinese medicine muskone, dragons blood, frankincense and myrrh gum; oil phase mainly comprises mixed aromatic plant oil (paroline, cinnamon oil, eugenol type basil oil, eucalyptus oil and gaultherolin); compound penetrant comprises laurocapram, borneol, muskone and dementholized peppermint oil; the aerosol also comprises an emulsifier, a cosolvent and a propellant; the preparation forms nano micro emulsion (25 to 80 nm); and the aerosol performs nanocrystallization homogeneity to precious traditional Chinese medicine in the preparation and spreads the precious traditional Chinese medicine to a microemulsified system, the microemulsified system adopts an oily system W / O with good biological adhesiveness to skin, medicine can be directly infiltrated into skin and directly reach wounded parts, and effects of rapid pain stopping and inflammation diminishing are achieved. Compared with frankincense rheumatism plaster, the aerosol has better local permeability, has no skin irritation and anaphylaxis, and is rapid for pain stopping.

Description

technical field [0001] The invention relates to an aerosol, in particular to a frankincense rheumatism aerosol for treating rheumatic bone pain, and belongs to the technical field of aerosol production. Background technique [0002] Rheumatic osteoarthritis is still a common disease that plagues many middle-aged and elderly people. According to statistics, there are about 400 million rheumatic patients worldwide, which is the largest disease group in the medical field; in China, rheumatoid arthritis 1. Patients with rheumatoid arthritis account for 18% of the total population, and the incidence rate in humid areas in my country is as high as 40%. market. However, due to the difference in the way of administration and the dosage form, the treatment effect of the disease varies too much, and even the treatment is delayed. [0003] Osteoarthritis (OA) is a chronic progressive joint disease characterized by joint pain, articular cartilage degeneration and bone hyperplasia. Pain ...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K9/12A61P29/00A61K35/55
Inventor 夏敏廖小丹汪怡林柳清林青霞韩小翠
Owner 广东同德药业有限公司
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