Adsorbent and method for producing same

A technology of adsorption materials and monomers, which is applied in the direction of material separation, analytical materials, chemical instruments and methods, etc., and can solve the problems of decreased retention capacity and inability to show solid phase extraction performance, etc.

Inactive Publication Date: 2013-01-16
HITACHI HIGH-TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, since the surface is covered with hydrophilic groups, the ability to hold molecules with a non-polar structure on the surface of the adsorbent decreases, failing to exhibit sufficient SPE performance
In addition, since the surface is very hydrophilic, there are unexpected adsorption of impurities other than pharmaceuticals, and detachment hindrance due to strong adsorption between pharmaceuticals and adsorbents, which is different from hydrophobic-hydrophilic monomer copolymers. The problem

Method used

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  • Adsorbent and method for producing same
  • Adsorbent and method for producing same
  • Adsorbent and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0272] (Example 1) Preparation of Divinylbenzene-Triallyl Isocyanurate Copolymer

[0273] A 500 mL separable flask was charged with 2.0 g of hydroxypropyl cellulose (HPC, manufactured by Aldrich, average molecular weight ~ 10,000, viscosity 5 cP (2 wt% aqueous solution, 20°C)) and 100 mL of water, and stirred until completely dissolved. Next, 7.84 g (0.06 mol) of divinylbenzene (DVB, manufactured by Aldrich, a mixture of 80% divinylbenzene + 19% ethylvinylbenzene), triallyl isocyanurate (TAIC, Tokyo Chemical Industry Co., Ltd.) were mixed. 14.95 g (0.06 mol) of toluene (manufactured by Wako Pure Chemical Industries, Ltd.), 11.5 g of toluene (manufactured by Wako Pure Chemical Industries, Ltd.), and 0.22 g of azobisisobutyronitrile (AIBN, manufactured by Tokyo Chemical Industry Co., Ltd.) were completely dissolved and put into a separable flask. The nitrogen introduction pipe and the cooling pipe were connected to the separable flask, and the polymerization system was stirred f...

Embodiment 2）

[0274] (Example 2) Preparation of Divinylbenzene-Triallyl Cyanurate Copolymer (1)

[0275] A 500 mL separable flask was charged with 2.0 g of hydroxypropyl cellulose (HPC, manufactured by Aldrich, average molecular weight ~ 10,000, viscosity 5 cP (2 wt% aqueous solution, 20°C)) and 100 mL of water, and stirred until completely dissolved. Next, 7.8 g (0.06 mol) of divinylbenzene (DVB, manufactured by Aldrich, a mixture of 80% divinylbenzene + 19% ethylvinylbenzene), triallyl cyanurate (TACy, manufactured by Tokyo Chemical Industry Co., Ltd.) were mixed. ) 15.0 g (0.06 mol), 11.5 g of toluene (manufactured by Wako Pure Chemical Industries, Ltd.), and 0.2 g of azobisisobutyronitrile (AIBN, manufactured by Tokyo Chemical Industry Co., Ltd.), were completely dissolved, and then placed in a separable flask. The nitrogen introduction pipe and the cooling pipe were connected to the separable flask, and the polymerization system was stirred for 30 minutes using a stirring blade while p...

Embodiment 3）

[0276] (Example 3) Preparation of Divinylbenzene-Triallyl Cyanurate Copolymer (2)

[0277] A 500 mL separable flask was charged with 6.0 g of hydroxypropyl cellulose (HPC, manufactured by Aldrich, average molecular weight ~ 10,000, viscosity 5 cP (2 wt% aqueous solution, 20°C)) and 200 mL of water, and stirred until completely dissolved. Next, 12.5 g (0.10 mol) of divinylbenzene (DVB, manufactured by Aldrich, a mixture of 80% divinylbenzene + 19% ethylvinylbenzene), triallyl cyanurate (TACy, manufactured by Tokyo Chemical Industry Co., Ltd.) were mixed. ) 6.0 g (0.02 mol), 8.0 g of toluene (manufactured by Wako Pure Chemical Industries, Ltd.), and 0.2 g of azobisisobutyronitrile (AIBN, manufactured by Tokyo Chemical Industry Co., Ltd.), were completely dissolved, and then placed in a separable flask. The nitrogen introduction pipe and the cooling pipe were connected to the separable flask, and the polymerization system was stirred for 30 minutes using a stirring blade while pu...

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Abstract

Disclosed are: an adsorbent which enables highly efficient and excellently selective solid phase extraction of a solute with a wide range of chromatography polarity, including high-polarity solute molecules, while suppressing adsorption of impurities; and a solid phase extraction method. Specifically disclosed is a heterocyclic ring-containing copolymer adsorbent which is characterized by being composed of a copolymer that is formed from a multifunctional heterocyclic ring-containing monomer, which has a heterocyclic ring that contains at least two heteroatoms in the ring structure, and a monomer that is copolymerizable with the multifunctional heterocyclic ring-containing monomer. The heterocyclic ring-containing copolymer adsorbent is also characterized in that the main chain structure of the adsorbent is configured of the multifunctional heterocyclic ring. Also specifically disclosed is a solid phase extraction method which comprises a step wherein a solution, which contains low-polarity solute molecules, medium-polarity solute molecules or high-polarity solute molecules as a solute, is brought into contact with the heterocyclic ring-containing copolymer adsorbent so that one or more kinds of solutes are selectively adsorbed and held by the adsorbent.

Description

technical field [0001] The present invention relates to an adsorbent material, a method for producing the same, and a solid phase extraction method using the adsorbent material. Background technique [0002] In recent years, the micro-analysis technology of drug concentration in biological samples has been advanced, and clinical pharmacology studies based on the drug concentration have been carried out for many drugs. As a result, it was found that the pharmacological action is more strongly dependent on the drug concentration than the dose, and the blood drug concentration is an important criterion for judging the therapeutic effect and the manifestation of side effects. In addition, it has been found that a considerable part of the drugs whose therapeutic effects are considered to have large individual differences do not originate from individual differences in susceptibility, but rather from individual differences in drug concentrations. [0003] For drugs with strong si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/281G01N30/88
CPCB01J2220/62B01J20/285B01J2220/82G01N30/7233C08F212/36C08F226/06C08F220/281C08F226/10C08F222/06C08F218/18C08F220/56
Inventor 布重纯香川博之伊藤伸也神田胜弘和气泉荒谷康太郎田村辉美
Owner HITACHI HIGH-TECH CORP
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