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Ibuprofen oral dispersing film agent

A film and dispersion technology, which is applied in the direction of anti-inflammatory agents, non-central analgesics, tablet delivery, etc., can solve the problems of complex preparation process of orally disintegrating tablets, inconvenient quantification and carrying, difficulty in swallowing, etc., to achieve Considerable economic and social benefits, avoiding the inconvenience of taking it, and the effect of rapid onset

Inactive Publication Date: 2013-02-20
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The convenient and quick-acting administration method is of great significance for the rapid treatment of cough and phlegm: injection administration has poor compliance for patients and has strong adverse reactions; oral tablets (common tablets, dispersible tablets, effervescent tablets, etc.) Tablets), capsules and granules need to be taken with water, disintegrate and dissolve in the gastrointestinal tract to take effect, slow onset, inconvenient, difficult to apply

Method used

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  • Ibuprofen oral dispersing film agent
  • Ibuprofen oral dispersing film agent
  • Ibuprofen oral dispersing film agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prescription (dose: 20mg):

[0019]

[0020] Process:

[0021] Dissolve the above-mentioned amount of polyethylene glycol 1000 and propylene glycol in the aqueous solution, and then add the prescribed amount of polyvinyl alcohol under stirring state after completely dissolving, and fully stir and disperse to obtain a glue solution. Add the ibuprofen and mix well. Degas or let stand overnight to remove air bubbles. This glue solution was coated on a PET film.

[0022] Easy and uniform coating; the film obtained by cutting is white, with good flexibility, slow disintegration, poor taste, bitter taste, long duration, sticky to teeth.

Embodiment 2

[0024] Prescription (dose: 20mg):

[0025]

[0026] Process:

[0027] Dissolve the above-mentioned amount of glycerin in the aqueous solution first, and then add the prescribed amount of hypromellose under stirring state after it is completely dissolved, and fully stir and disperse to obtain a glue solution. Then add croscarmellose sodium, sorbitol, sucralose and ibuprofen and stir evenly. Degas or let stand overnight to remove air bubbles. This glue solution was coated on a PET film.

[0028] Coating is difficult and uneven; the film obtained by cutting is white, with good flexibility, slow disintegration, poor taste and sticky teeth. After standing for a period of time, it was found that there was oily substance on the surface of the diaphragm, and white crystals were precipitated. The crystals were bitter, and it was suspected to be ibuprofen.

Embodiment 3

[0030] Prescription (dose: 20mg):

[0031]

[0032] Process:

[0033] Dissolve the above-mentioned amount of propylene glycol in the aqueous solution first, and then add the prescribed amount of hypromellose under stirring state after completely dissolving, and fully stir and disperse to obtain a glue solution. Then add ibuprofen, hydroxypropyl cellulose and microcrystalline cellulose ph101 in the prescribed amount and stir evenly. Degas or let stand overnight to remove air bubbles. This glue solution was coated on a PET film.

[0034] Coating is difficult and uneven; the film obtained by cutting is translucent and granular, with good flexibility, slow disintegration, general taste and sticky teeth.

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PUM

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Abstract

The invention relates to an ibuprofen oral dispersing film agent which comprises ibuprofen, a film-forming material, purified water, plasticizer and the like, wherein the effective dosage of ibuprofen is selected to be 20mg, 30mg or 40mg. The product can be rapidly dispersed or dissolved in the oral cavity, and has the functions of analgesia, abatement of fever and inflammation reduction.

Description

technical field [0001] The invention relates to an ibuprofen oral dispersible film with different doses, the doses are respectively 20 mg, 30 mg and 40 mg, a preparation method and properties in vitro. The preparation has a beautiful appearance, is convenient to carry, is easy to take, and disintegrates quickly, and can disintegrate in the oral cavity without taking water, and is especially suitable for the elderly, children, and patients who have difficulty swallowing. The ibuprofen orodispersible film is used for analgesic, antipyretic and anti-inflammatory effects. Background technique [0002] Ibuprofen, 2-(4-isobutylphenyl)propionic acid, is a well-known drug with analgesic, anti-inflammatory and antipyretic properties. It is usually sold as racemic ibuprofen (equal amounts of S(+) ibuprofen and R(-) ibuprofen enantiomers). It may also be in the form of the pure enantiomers, in particular S(+) ibuprofen, which is the recognized active form of racemic ibuprofen. Ibupr...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/192A61P29/00
Inventor 王丽
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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