Method for preparing invert sugar and electrolytes injection

A technology for electrolyte injection and invert sugar, applied in the field of medicine, can solve the problems of data and publication without pH adjustment, and achieve the effect of improving safety

Active Publication Date: 2013-03-06
HAISCO PHARMA GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the literature does not provide data and publications on the pH adjustment during the preparation of the formulation.

Method used

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  • Method for preparing invert sugar and electrolytes injection
  • Method for preparing invert sugar and electrolytes injection
  • Method for preparing invert sugar and electrolytes injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add an appropriate amount of water for injection into the concentrated preparation tank, put in the prescribed amount of glucose, fructose, magnesium chloride, potassium chloride, sodium chloride, sodium lactate, sodium dihydrogen phosphate, and sodium bisulfite, and stir until completely dissolved.

[0024] Add 0.05% (w / v) activated carbon for needles that has been moistened and boiled into the concentrated preparation tank, and after stirring for 15 minutes, turn on the concentrated preparation's own circulation system to decarbonize for 15-20 minutes, and pump the liquid medicine into the thin preparation tank. After the delivery, add water for injection into the concentrated preparation tank, cycle and wash it three times, and pump the cleaning water into the thin preparation tank.

[0025] Add water for injection to the required preparation amount in the dilute preparation tank, stir for 15-20 minutes, initially measure the pH value of the liquid, adjust the pH valu...

Embodiment 2

[0028] Add an appropriate amount of water for injection into the concentrated preparation tank, put in the prescribed amount of glucose, fructose, magnesium chloride, potassium chloride, sodium chloride, sodium lactate, sodium dihydrogen phosphate, and sodium bisulfite, and stir until completely dissolved.

[0029] Add 0.05% (w / v) activated carbon for needles that has been moistened and boiled into the concentrated preparation tank, and after stirring for 15 minutes, turn on the concentrated preparation's own circulation system to decarbonize for 15-20 minutes, and pump the liquid medicine into the thin preparation tank. After the delivery, add water for injection into the concentrated preparation tank, cycle and wash it three times, and pump the cleaning water into the thin preparation tank.

[0030] Add water for injection to the required preparation amount in the dilute preparation tank, stir for 15-20 minutes, initially measure the pH value of the liquid, adjust the pH valu...

Embodiment 3

[0033] Add an appropriate amount of water for injection into the concentrated preparation tank, put in the prescribed amount of glucose, fructose, magnesium chloride, potassium chloride, sodium chloride, sodium lactate, sodium dihydrogen phosphate, and sodium bisulfite, and stir until completely dissolved.

[0034] Add 0.08% (w / v) activated carbon for needles that has been moistened and boiled into the concentrated preparation tank, and after stirring for 15 minutes, turn on the concentrated preparation's own circulation system to decarbonize for 15-20 minutes, and pump the liquid medicine into the thin preparation tank. After the delivery, add water for injection into the concentrated preparation tank, cycle and wash it three times, and pump the cleaning water into the thin preparation tank.

[0035] Add water for injection to the required preparation amount in the dilute preparation tank, stir for 15-20 minutes, initially measure the pH value of the liquid, adjust the pH valu...

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PUM

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Abstract

The invention belongs to the field of medical technologies, and mainly relates to a method for preparing an invert sugar and electrolytes injection. Specifically, the method disclosed by the invention improves the stability and safety of compatibility from the process source, and the invert sugar and electrolytes injection prepared by using the method disclosed by the invention can be safely compatible with 70 kinds of commonly used clinical medicines such as cefodizime sodium, thereby improving the safety, applicability and convenience of clinical medications.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of invert sugar electrolyte injection which improves incompatibility. Background technique [0002] Invert sugar electrolyte injection is a sterilized aqueous solution of equal amounts of fructose and glucose (invert sugar), sodium chloride, potassium chloride, magnesium chloride, sodium dihydrogen phosphate and sodium lactate, which can provide patients with water, electrolytes and energy, and produce Diuretic effect and metabolic alkalinization effect, the lactate contained in it is metabolized in the liver to generate glycogen, which is in H + Participate in the final generation of CO 2 and water. Clinically, it is suitable for rehydration therapy for patients who need non-oral supplementation of water or energy and electrolytes. It is widely used at home and abroad, and it is included in the United States Pharmacopoeia because of its good ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K9/08A61P3/12A61P3/02A61K31/7004A61K33/06A61K33/14A61K31/19A61K33/04
Inventor 郑伟
Owner HAISCO PHARMA GRP INC
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