Propolis fat emulsion preparation and preparation method thereof

Abstract

The invention provides a fat emulsion preparation of a propolis extractive. The preparation comprises principal active components in propolis and is prepared by dissolving the propolis extractive by using vegetable oil and adopting phosphatide and monoglyceride as emulsifiers, oleic acid, linoleic acid, cholic acid compounds or duplex fatty glyceride as a co-emulsifier, an additive and water for injection. According to the invention, a nutritional supplement fat emulsion widely used clinically is firstly used as a drug delivery carrier of the propolis extractive; the fat emulsion preparation is nontoxic, even in particle size, long in quality guarantee period, high in bioavailability and good in stability; the physicochemical property of the propolis after high-pressure sterilization is not obviously changed; the administration can be finished through intravenous injection, intramuscular injection, orally-taken mode, external use mode and the like; the medical and healthy functions of the propolis are brought into full play; the health condition of a human body is improved; and the preparation can also be used as a veterinary drug used for improving the disease resistance of livestock.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a fat emulsion preparation, in particular to a propolis fat emulsion preparation and a preparation method thereof. Background technique [0002] Propolis is a colloidal solid with an aromatic smell that is processed by bees from the resin (gum) collected from plant spores or tree trunks, mixed with the secretions of their palate glands and wax glands. Studies have proved that the rich and unique biologically active substances contained in propolis have various functions such as antibacterial, anti-inflammatory, antipruritic, anti-oxidative, immune-enhancing, hypoglycemic, hypolipidemic, and anti-tumor, and have a wide range of medical effects on the human body. ,Health effects. [0003] Propolis currently on the market mainly has the following dosage forms: soft capsules, hard capsules, propolis tablets, propolis liquid (wine solution and aqueous solution) and intramuscular injection. Howe...

AI Technical Summary

Problems solved by technology

However, due to the complex composition and poor solubility of propolis extract itself, the oral bioavailability of capsules and tablets is not high; the main active ingredients of propolis extract are water-insoluble, so the main active ingredients of propolis liquid are in its wine solution, while Alcohol solution has large limitations, and people who are allergic to alcohol and who are not suitable for drinking can't take it; Chinese patent 201010515531.6 "Preparation Process of Propolis Injection" discloses an injection that completely uses methanol, ethanol, propylene glycol and glycerol triacetate as propolis solvents. Both safety of use and absorption efficiency are questionable; patent CN201110177123.9 , CN201110177131.3 and CN201110177129.6 The preparation methods of propolis injections for the prevention of duck plague, duck hemorrhagic ovariitis and type I duck viral hepatitis are disclosed respectively. The above three patents all select propolis aqueous solution as the main component of the injection, but considering the The main active ingredients of flavonoids and terpenes are water-insoluble, and the content in the propolis aqueous solution is very small, so the effect of the injection prepared by the above patent is very limited; the patent CN1879656B "Solid water-soluble propolis composition and preparation method thereof" discloses a kind of β-cyclodextrin inclusion anhydrous ethanol propolis extract to prepare solid water-soluble propolis, although the problem of poor solubility of propolis in aqueous solution has been solved, it has been Studies have proved that β-cyclodextrin is harmful to human kidneys, and may cause toxic side effects such as hemolysis and necrosis at the injection site; patent CN1237893C "A Water-Soluble Propolis Extraction Method and Its Application" discloses a method of making the active ingredients of propolis into a water-soluble extract, but simply dissolving the propolis with water and some surfactants as solvents to obtain a water-soluble propolis extract , not only the active ingredients dissolved from propolis are incomplete, but also the preparation stability of the prepared water-soluble propolis extract is poor

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