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Application of ombination of esveratrol and piperine used for preparation of medicament for treatment of depression

A technology of resveratrol and piperine, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, nervous system diseases, etc., can solve the problem of increasing amine neurotransmitters in the brain

Inactive Publication Date: 2013-03-20
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether trans-resveratrol increases the level of amine neurotransmitters in the brain through the inhibition of MAO activity is still inconclusive.

Method used

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  • Application of ombination of esveratrol and piperine used for preparation of medicament for treatment of depression
  • Application of ombination of esveratrol and piperine used for preparation of medicament for treatment of depression
  • Application of ombination of esveratrol and piperine used for preparation of medicament for treatment of depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: Mouse tail suspension test, forced swimming test, autonomous activity test, PCPA test, reserpine test

[0008] 1. Test drugs

[0009] Name: Resveratrol, Piperine

[0010] Properties: Resveratrol, off-white fine powder, special gas, light taste, piperine extracted from Polygonum cuspidatum, white crystal powder

[0011] Source: purchased from Shaanxi Senfu Biotechnology Co., Ltd., with a purity of 98%

[0012] Drug preparation: piperine was dissolved in 0.5% sodium carboxymethyl cellulose, made into 2.5 mg / kg, and injected intraperitoneally into mice at a dose of 0.1 ml / 10 g. Resveratrol was dissolved in 0.5% sodium carboxymethylcellulose, and formulated into five doses of 1.25mg / kg, 2.5mg / kg, 5mg / kg, 10mg / kg, and 20mg / kg respectively, and the dosage was 0.1ml / 10g Mice were administered orally.

[0013] 2. Control drug

[0014] Imipramine hydrochloride (imipramine hydrochloride), fluoxetine (fluoxetine hydrochloride), PCPA (p-chlorophenylalanine HCl): pur...

Embodiment 2

[0043] Embodiment 2; Mouse monoamine oxidase, monoamine transmitter and its metabolite content determination

[0044] 1. Test drug: same as Example 1

[0045] 2. Positive control drugs: dihydrobromokynurenamide, 4-hydroquinoline, selegiline, chlorogiline, 5-hydroxytryptamine (5-HT), norepinephrine (NA), dopamine (DA), 5- Hydroxyisobutyric acid (5-HIAA) and dihydroxyphenylbutyric acid (DOPAC) were purchased from Sigma, USA. Moclobemide was purchased from China Institute for the Control of Pharmaceutical and Biological Products.

[0046] 3. Experimental method

[0047] ① Determination of monoamine transmitters and their metabolites:

[0048] 60min after administration (piperine i.p.; resveratrol, p.o.; imipramine, i.p.), the mice were quickly decapitated, and the frontal cortex, hippocampus, striatum and hypothalamus were quickly isolated on ice. After weighing, put it into an Eppendorf tube and store it in a -80°C refrigerator. Add 200μl ice 0.4mol / L HCLO4 to every 100mg o...

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Abstract

The present invention relates to a drug combination therapy. The combination of esveratrol and piperine are used for treating depression. Animal experiments show that the combination of esveratrol and piperine has a good anti-depressant effect, and is a relatively promising natural anti-depressant medicament, and can be used for the preparation of a medicament for the treatment of depression.

Description

technical field [0001] The invention relates to a new application of resveratrol combined with piperine, in particular to the application of preparing medicine for treating depression. Background technique [0002] Depression is an affective disorder mental illness that seriously affects physical and mental health. With the increasing pressure of people's survival and development, depression has become a common disease in modern society. Patients with major depressive disorder show reflexive changes in monoamine neurotransmitters in the brain, especially norepinephrine (NE) and 5-hydroxytryptamine (5-HT). Currently, drug therapy is the preferred option for the treatment of depression. Several typical antidepressants clinically exert antidepressant effects by increasing the levels of monoamines such as 5-HT and NE. But most drugs have adverse effects, and the treatment effect is not very good. Therefore, the research on the effectiveness and safety treatment factors of dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4525A61K31/05A61P25/24
Inventor 潘建春徐英
Owner WENZHOU MEDICAL UNIV
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