Application of tetrandrine in hepatic stellate cell migration inhibition drug preparation
Patent Information
- Authority / Receiving Office
- CN Β· China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
- Publication Date
- 2013-03-27
- Estimated Expiration
- Not applicable Β· inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of tetrandrine in the preparation of medicines for inhibiting the migration of hepatic stellate cells. Background technique
[0002] Tetrandrine, also known as tetrandrine, is the main biologically active component of Tetradontidae plant, belonging to the bisbenzyl isoquinoline compound, is Ca 2+ Antagonist, which can both block membrane voltage-gated channel-mediated Ca 2+ Influx, can also block receptor-gated channels interfering with intracellular Ca 2+ distribution, thereby blocking relevant pathological processes; such as inhibiting the proliferation of fibroblasts, the synthesis and excretion of ECM (extracellular matrix, extracellular matrix), and the promotion of fibrosis by growth factors. Studies have found that it has a good therapeutic effect on the cardiovascular system, liver, pulmonary fibrosis, and inflammatory response. ...