Application of tetrandrine in hepatic stellate cell migration inhibition drug preparation

A technology of hepatic stellate cells and tetrandrine, which is applied in the application field of medicine and can solve problems such as no relevant reports.

Inactive Publication Date: 2013-03-27
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the role of tetrandrine in inhibiting the migration of hepatic stellate cells

Method used

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  • Application of tetrandrine in hepatic stellate cell migration inhibition drug preparation
  • Application of tetrandrine in hepatic stellate cell migration inhibition drug preparation
  • Application of tetrandrine in hepatic stellate cell migration inhibition drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The tetrandrine of the present invention is made into tablets according to methods known to those skilled in the art. Tetrandrine tablets, each tablet contains 50mg of tetrandrine, 60mg of microcrystalline cellulose, 20mg of micronized silica gel, 10mg of lactose, and 0.7mg of magnesium stearate. Usage: 1 tablet each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 2

[0068] The tetrandrine of the present invention is made into capsules according to methods known to those skilled in the art. Tetrandrine capsules, each containing 50mg tetrandrine. Usage: 1 capsule each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 3

[0070] The tetrandrine of the present invention is prepared into granules according to methods known to those skilled in the art. Tetrandrine granules, each bag contains 50mg of tetrandrine, 60mg of microcrystalline cellulose, 20mg of micronized silica gel, 0.7mg of stearic acid, and 20mg of lactose. Usage: 1 bag each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

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Abstract

The present invention discloses an application of tetrandrine in hepatic stellate cell migration inhibition drug preparation. According to the present invention, a PDGF-induced human hepatic stellate cell line (LX-2) migration screening platform is designed, and results show that PDGF-induced hepatic stellate cell (HSC) migration can be inhibited with 10<-4>-10<-7> mol/L tetrandrine.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of tetrandrine in the preparation of medicines for inhibiting the migration of hepatic stellate cells. Background technique [0002] Tetrandrine, also known as tetrandrine, is the main biologically active component of Tetradontidae plant, belonging to the bisbenzyl isoquinoline compound, is Ca 2+ Antagonist, which can both block membrane voltage-gated channel-mediated Ca 2+ Influx, can also block receptor-gated channels interfering with intracellular Ca 2+ distribution, thereby blocking relevant pathological processes; such as inhibiting the proliferation of fibroblasts, the synthesis and excretion of ECM (extracellular matrix, extracellular matrix), and the promotion of fibrosis by growth factors. Studies have found that it has a good therapeutic effect on the cardiovascular system, liver, pulmonary fibrosis, and inflammatory response. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P1/16
Inventor 徐列明张展
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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