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Method for preparing bile and patchouli rhinitis tablets and application

A technology of Danxiang Biyan Tablets and Patchouli, which is applied in the field of preparation of Danxiang Biyan Tablets, can solve the problems of large dosage of patients, rough process, affecting clinical application, etc., and achieve the effect of reducing dosage

Active Publication Date: 2013-03-27
浙江音置声学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Danxiang Biyan Tablets. However, the method of powdering and boiling in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient. Taking it seriously affects the clinical application of this product

Method used

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  • Method for preparing bile and patchouli rhinitis tablets and application

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Experimental program
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Effect test

Embodiment 1

[0025] Take pig bile paste 15g, patchouli 560g, angelica dahurica 560g, cocklebur 450g, goose not eating grass 375g, nepeta 250g, honeysuckle 250g, wild chrysanthemum 250g, menthol 1.5g, patchouli, nepeta, honeysuckle , wild chrysanthemum, added to the CO2 supercritical extractor, ethanol as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is After 150 minutes, the supercritical extract was obtained and set aside; take Angelica dahurica, cocklebur, and goose herb-eating herb, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400W, and the extraction is performed twice, each time For 4 minutes, the extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times ...

Embodiment 2

[0028] Take pig bile paste 15g, patchouli 560g, angelica dahurica 560g, cocklebur 450g, goose not eating grass 375g, nepeta 250g, honeysuckle 250g, wild chrysanthemum 250g, menthol 1.5g, patchouli, nepeta, honeysuckle , wild chrysanthemum, added to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained, which is used for later use; take Angelica dahurica, cocklebur, and goose herb, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. Extraction power 600W, extraction 2 times, 8 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times column volume eluate, recov...

Embodiment 3

[0031] Take pig bile paste 15g, patchouli 560g, angelica dahurica 560g, cocklebur 450g, goose not eating grass 375g, nepeta 250g, honeysuckle 250g, wild chrysanthemum 250g, menthol 1.5g, patchouli, nepeta, honeysuckle , wild chrysanthemum, added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, and it is used for later use; take Angelica dahurica, cocklebur, and goose herb, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. Extraction power 500W, extraction 2 times, 6 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times column volume eluate, recover...

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Abstract

The invention provides a method for preparing bile and patchouli rhinitis tablets. The rhinitis tablets are prepared from 15g of porcine bile paste, 560g of patchouli, 560g of dahurian angelica, 450g of cocklebur fruit, 375g of centipeda, 250g of schizonepeta, 250g of honeysuckle, 250g of wild chrysanthemum and 1.5g of menthol serving as raw medicaments by adopting supercritical extraction and microwave extraction, so that the cocklebur fruit content is greatly improved. The invention also provides application of the bile and patchouli rhinitis tablets in preparation of a medicament for inhibiting propagation of human large cell lung cancer NC1-H460 cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Danxiang Biyan Tablets. Background technique [0002] Danxiang Biyan Tablets are recorded in the standard WS3-B-0914-91 of the Ministry of Health, consisting of 15g of pig bile paste, 560g of patchouli, 560g of Angelica dahurica, 450g of Xanthium, 375g of Goose Bubiograss, 250g of Schizonepeta, 250g of honeysuckle, wild 250g of chrysanthemum and 1.5g of menthol are made as raw materials, which can reduce inflammation and clear away heat, dispel wind and cold, open orifices and relieve pain. For chronic simple rhinitis, allergic rhinitis. Acute and chronic rhinitis paranasal sinusitis. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Danxiang Biyan Tablets. However, the method of powdering and boiling in water is rough a...

Claims

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Application Information

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IPC IPC(8): A61K36/538A61K9/20A61P11/02A61P35/00
Inventor 不公告发明人
Owner 浙江音置声学科技有限公司
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