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Method for preparing gynecological menstruation regulating tablets and application

A technology of gynecological menstruation regulation and Rhizoma Chuanxiong, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., which can solve the problems of large dosage, rough process, and many impurities for patients, and achieve the effect of reducing dosage

Inactive Publication Date: 2013-03-27
章丘市妇幼保健院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Fuke Tiaojing Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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  • Method for preparing gynecological menstruation regulating tablets and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 144g of angelica, 16g of Chuanxiong, 400g of vinegar-roasted cyperus, 23g of bran-fried Atractylodes macrocephala, 12g of white peony, 12g of red peony, 32g of vinegar-roasted corydalis, 48g of rehmannia glutinosa, 80g of jujube, and 11g of licorice. Attached, add to CO2 supercritical extractor, ethanol is used as entrainer, the entrainer accounts for 4% of the volume of the total extraction solvent, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 150min. Obtain the supercritical extract and set it aside; take the rest of the traditional Chinese medicine, pulverize it, add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, extract power 400W, extract twice, each time for 4 minutes, combine the extracts, concentrate, add Put it on the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover the...

Embodiment 2

[0028] Take 144g of angelica, 16g of Chuanxiong, 400g of vinegar-roasted cyperus, 23g of bran-fried Atractylodes macrocephala, 12g of white peony, 12g of red peony, 32g of vinegar-roasted corydalis, 48g of rehmannia glutinosa, 80g of jujube, and 11g of licorice. attached, added to the CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times t...

Embodiment 3

[0031] Take 144g of angelica, 16g of Chuanxiong, 400g of vinegar-roasted cyperus, 23g of bran-fried Atractylodes macrocephala, 12g of white peony, 12g of red peony, 32g of vinegar-roasted corydalis, 48g of rehmannia glutinosa, 80g of jujube, and 11g of licorice. attached, added to the CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collec...

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Abstract

The invention provides a method for preparing gynecological menstruation regulating tablets. The menstruation regulating tablets are prepared from 144g of Chinese angelica, 16g of Szechuan lovage rhizome, 400g of vinegar baked rhizoma cyperi, 23g of bran baked bighead atractylodes rhizome, 12g of white peony root, 12g of red peony root, 32g of vinegar baked corydalis tuber, 48g of prepared rehmannia root, 80g of jujube and 11g of licorice serving as raw medicaments by adopting supercritical extraction and microwave extraction, so that the ferulic acid content is greatly improved. The invention also provides application of the gynecological menstruation regulating tablets in preparation of a medicament for inhibiting propagation of human nasopharyngeal carcinoma CNE-2Z cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Fuke Tiaojing Tablets. Background technique [0002] Fuke Tiaojing Tablets are recorded in the standard WS3-B-0937-91 of the Ministry of Health. It consists of 144g of Angelica, 16g of Chuanxiong, 400g of Coriander Cyperus, 23g of Bran-fried Atractylodes Rhizome, 12g of Radix Paeoniae Alba, 12g of Radix Paeoniae Rubra, 32g of Corydalis Corydalis and 48g of Rehmannia glutinosa , jujube 80g, and licorice 11g are made as raw materials, which can nourish blood, regulate menstruation, and relieve pain. For irregular menstruation, menstrual abdominal pain. [0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Fuke Tiaojing Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many ...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61K9/20A61P15/00A61P29/02A61P7/06A61P35/00
Inventor 不公告发明人
Owner 章丘市妇幼保健院
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