Method for extracting delta-elemene
An extraction method and technology of elemene, which is applied in the field of extraction of δ-elemene, can solve the problems that cannot be quantified, the content of γ-elemene and δ-elemene can only be estimated, and there is no separation and extraction method, etc. To achieve the effect of improving adsorption performance and improving purity
Active Publication Date: 2015-03-11
YUAN INT GROUP
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Problems solved by technology
There is no report on the extraction of γ-elemene and δ-elemene
[0004] In addition, because there is no suitable separation and extraction method, there is no reference standard that can be used when detecting the content of γ-elemene and δ-elemene, resulting in γ-elemene and δ-elemene in pharmaceutical ingredients content can only be estimated but not quantified
Method used
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Embodiment 1
[0019] (1) Use 2300ml of zedoary oil with a δ-elemene content of about 1.8% as the raw material, place it in the heating kettle of the rectification tower to start rectification, and control the rectification column (height is 140cm, inner diameter is 3.5cm, and the diameter is 3mm × 3mm long stainless steel mesh roll as filler, the column efficiency is more than 40 plates), the vacuum inside is 180Pa, the fractionation ratio is 2:1, and the fractions at the temperature of 128-135°C are collected.
[0020] (2) Use the distillate obtained in step (1) as raw material, place it in the heating kettle of the precision rectification tower, and carry out precision rectification. The 2mm stainless steel mesh roll is used as packing, the column efficiency is more than 60 trays), the vacuum inside is 100Pa, the fractionation ratio is 4:1, and the fractions with a temperature of 120-125°C are collected.
[0021] (3) Use the distillate obtained in step (2) as raw material, place it in the...
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Abstract
The invention provides a method for extracting delta-elemene. The method comprises the following steps of: (1) carrying out ordinary rectification by using zedoary turmeric oil of which the delta-elemene content is more than 1.5% as the raw material, wherein the vacuum degree inside a rectifying column is 150-300Pa and the rectification ratio is 2:1, and collecting distillate with a temperature of 128-135 DEG C; (2) carrying out primary fine rectification by using the distillate obtained in the step (1) as the raw material, subsequently carrying out the secondary fine rectification by using the obtained distillate as the raw material, wherein the rectification ratios are different (4:1 in the primary fine rectification, and 6:1 in the secondary fine rectification) and the vacuum degrees in precise rectifying columns are both set as 50-150Pa, and collecting distillate with a temperature of 120-125 DEG C; and (3) carrying out axial compression high pressure column separation by using the obtained distillate in the step (2) as the raw material. According to the method, a method of primary ordinary rectification, secondary precise rectification and axial compression high pressure column separation is utilized, delta-elemene with high purity is obtained, and the difficult problem that no reference substances of the delta-elemene are available for years is solved.
Description
technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a method for extracting delta-elemene. Background technique [0002] Elemene is an active ingredient in zedoary oil. It contains three isomers of δ-elemene, β-elemene and γ-elemene. It is a national second-class anticancer drug. Cancer effect and lower toxic side effects have been widely recognized. [0003] The extraction of β-elemene has been documented in "Preparation method and composition of anticancer drugs with β-elemene as active ingredient" (CN 1200266A), but due to γ-elemene and δ-elemene Elemene is an isomer of β-elemene, so when preparing β-elemene, γ-elemene and δ-elemene will also be separated together, and more sophisticated extraction methods are required to obtain detach it. At present, there is no report on the extraction of γ-elemene and δ-elemene. [0004] In addition, because there is no suitable separation and extraction method, there is no ...
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IPC IPC(8): C07C13/19C07C7/04C07C7/12
Inventor 戴坚王若研史跃满李建赵志亮付冉
Owner YUAN INT GROUP