Extraction method of Gamma-elemene
An extraction method, the technology of elemene, which is applied in the field of extraction of γ-elemene, can solve the problems that cannot be quantified, the content of γ-elemene and δ-elemene can only be estimated, and there is no separation and extraction method, etc. To achieve the effect of improving adsorption performance and improving purity
Active Publication Date: 2013-03-27
YUAN INT GROUP
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Problems solved by technology
There is no report on the extraction of γ-elemene and δ-elemene
[0004] In addition, because there is no suitable separation and extraction method, there is no reference standard that can be used when detecting the content of γ-elemene and δ-elemene, resulting in γ-elemene and δ-elemene in pharmaceutical ingredients content can only be estimated but not quantified
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Embodiment 1
[0019] (1) Use 2150ml of zedoary oil with a content of γ-elemene of about 2.1% as raw material, place it in the heating kettle of the rectification tower to start rectification, and control the rectification column (height is 140cm, inner diameter is 3.5cm, and diameter is 3mm × 3mm long stainless steel mesh roll as packing, the column efficiency is more than 40 plates), the vacuum inside is 220Pa, the fractionation ratio is 2:1, and the fractions at the temperature of 148-155°C are collected.
[0020] (2) Use the distillate obtained in step (1) as raw material, place it in the heating kettle of the precision rectification tower, and carry out precision rectification. The 2mm stainless steel mesh roll is used as packing, the column efficiency is more than 60 trays), the vacuum inside is 130Pa, the fractionation ratio is 4:1, and the fractions with a temperature of 135-140°C are collected.
[0021] (3) Use the distillate obtained in step (2) as raw material, place it in the hea...
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The invention provides an extraction method of Gamma-elemene. The extraction method comprises the following steps of: (1) adopting zedoary oil with the content of Gamma-elemene being 2% as a material to carry out general distillation under the conditions that the vacuum degrees in distilling columns are 150-300Pa and the fractionation rate is 2:1, and collecting fractions with the temperatures of 148-155 DEG C; (2) adopting the fractions obtained in the step (1) as the materials to carry out primary precise distillation, then adopting the obtained fractions as the materials to carry out secondary precision distillation, setting the vacuum degrees in the precise distilling columns to be 50-150Pa, and collecting fractions with the temperatures of 135-140 DEG C; and (3) adopting the fractions obtained in the step (2) as the materials to carry out axial-compression high-pressure column separation. The extraction method adopting primary general distillation, secondary precise distillation and axial-compression high-pressure column separation, and has the advantages that the high-purity Gamma-elemene can be obtained, and the difficulty that the Gamma-elemene has no comparison products for use in many years is solved.
Description
technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a method for extracting gamma-elemene. Background technique [0002] Elemene is an active ingredient in zedoary oil. It contains three isomers of δ-elemene, β-elemene and γ-elemene. It is a national second-class anticancer drug. Cancer effect and lower toxic side effects have been widely recognized. [0003] The extraction of β-elemene has been documented in "Preparation Method and Composition of Anticancer Drugs Using β-Elemene as Active Ingredient" (CN1200266A), but due to γ-elemene and δ-elemene It is an isomer of β-elemene, so when preparing β-elemene, γ-elemene and δ-elemene will also be separated together, and more precise extraction methods are required to extract its separation. At present, there is no report on the extraction of γ-elemene and δ-elemene. [0004] In addition, because there is no suitable separation and extraction method, there is no refer...
Claims
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Login to View More IPC IPC(8): C07C13/19C07C7/04C07C7/12
Inventor 戴坚王若研史跃满李建赵志亮付冉
Owner YUAN INT GROUP