Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Infectious bronchitis virus attenuated vaccine strain

A bronchitis, chicken infectious technology, applied in the direction of antiviral agents, viruses/phages, biochemical equipment and methods, etc., can solve problems such as not yet commercialized, glandular stomach type IB cannot be effectively controlled, etc., and achieve good commercial products. Chemical development prospects, effective immune protection, and hereditary stable effects

Active Publication Date: 2013-03-27
YEBIO BIOENG OF QINGDAO
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many researches on vaccines used to prevent glandular gastric type infectious bronchitis at home and abroad, but none of them have been commercialized yet.
At the same time, due to the large number of IBV serotypes, there has been no attenuated strain with good cross-protection on the market, and the gastric type IB cannot be effectively controlled

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Infectious bronchitis virus attenuated vaccine strain
  • Infectious bronchitis virus attenuated vaccine strain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] The present invention will be further described below in conjunction with specific embodiments. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0010] One, the screening of chicken infectious bronchitis attenuated YB160 strain of the present invention

[0011] Use 10-11 day-old SPF chicken embryos to carry out continuous passage to attenuate the virulence of infectious bronchitis. In each generation, 4 SPF chicken embryos were inoculated through the allantoic cavity, and the attenuation evaluation was carried out for 160 generations. Get 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160 inoculated virus strains to infect 1-day-old SPF chickens. Results From the 80th generation...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an infectious bronchitis virus attenuated vaccine strain. The preservation number of the virus strain is China General Microbiological Culture Collection Center (CGMCC) No.6752. The screened attenuated vaccine strain is used for preparing vaccines for preventing and treating infectious bronchitis. The infectious bronchitis virus attenuated vaccine strain can be passed in chicken bodies continuously whether artificial infection or horizontal transmission infection, the phenomenon of virulence enhancement does not occur, the heredity is stable, and the strain conforms to the standard of no virulence enhancement of infectious bronchitis virus attenuated vaccine strains and can be developed commercially.

Description

technical field [0001] The invention belongs to the technical field of vaccine antigen screening, in particular to a chicken infectious bronchitis virus attenuated vaccine strain. Background technique [0002] Infectious bronchitis (IB) is an acute and highly contagious respiratory disease caused by infectious bronchitis virus (IBV). It is characterized by decreased egg quality and reduced egg quality; sick chickens often die due to respiratory, kidney or digestive tract infections. The disease was first reported in the United States by Schalk et al. in 1931, and in 1936 Beach and Hudson determined that the pathogen of the disease was a virus. So far, the disease has been widely prevalent in the world and has brought serious harm to the chicken industry. In my country, Kuang Ronglu (1972) first discovered the disease in Guangdong; by the late 1970s, Zheng Furong et al. in Hangzhou, Wu Zhida et al. in Shanghai, Ai Guoguang et al. in Beijing, Xin Chaoan et al. IBV. Rong Jun...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12N7/00A61K39/215A61P31/14C12R1/93
Inventor 范根成杜元钊宋新宇宫晓孙健王红徐保娟
Owner YEBIO BIOENG OF QINGDAO
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com