A compound tablet with a high content of chondroitin sulfate and a preparation method thereof

A chondroitin sulfate and composite tablet technology is applied in food preparation, medical preparations containing active ingredients, pharmaceutical formulations, etc., and can solve the problems of easy pockmarking of the coating and difficulty in disintegrating chondroitin sulfate swallowed tablets, etc. To achieve the effect of being beneficial to carboxylation, promoting bone mineralization rate and bone formation rate, and preventing and treating osteoporosis

Active Publication Date: 2014-03-26
杭州海王生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, through the selection of auxiliary materials and process optimization, the problems of difficult disintegration of high-content chondroitin sulfate swallowing tablets and pitting easily appearing in the coating are solved in the process production engineering. The product of the present invention has the advantages of smooth surface and stable quality. It takes 3-6 tablets to achieve the expected effect, easy to carry and take

Method used

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  • A compound tablet with a high content of chondroitin sulfate and a preparation method thereof
  • A compound tablet with a high content of chondroitin sulfate and a preparation method thereof
  • A compound tablet with a high content of chondroitin sulfate and a preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Screening of raw materials: 27% chondroitin sulfate, 28% glucosamine, 12% calcium phosphate, and 0.2% casein phosphopeptide were respectively passed through a 100-mesh sieve accounting for tablet mass ratio.

[0045] (2) Chondroitin sulfate granulation:

[0046] a. Add 0.8% povidone solution to the chondroitin sulfate treated in (1) to make a soft material.

[0047] b. Wet granules: Pass the chondroitin sulfate soft material prepared in (2)a through a 20-mesh sieve to make wet granules.

[0048] c. Drying: Dry the chondroitin sulfate wet granules prepared in (2) b at a temperature of 60° C. for 60-100 min until the water content of the granules is 2-4%.

[0049] d. Grain sizing: pass the dry chondroitin sulfate granules prepared in (2) c through a 40-mesh sieve. spare.

[0050] (3) Glucosamine, calcium phosphate, casein phosphopeptide, vitamin K 2 Granulation:

[0051] a, making soft material: fully mix (1) treated glucosamine, calcium phosphate, casein phospho...

Embodiment 2

[0058] (1) Screening of raw materials: 32% chondroitin sulfate, 25% glucosamine, 15% calcium phosphate and 0.4% casein phosphopeptide were passed through an 80-mesh sieve accounting for tablet mass ratio.

[0059] (2) soft material: the processed chondroitin sulfate, glucosamine, calcium phosphate, casein phosphopeptide and 0.6% vitamin K 2 A soft material is made, and the binder is a povidone solution, and the povidone accounts for 1.5% of the sheet weight.

[0060] (3) Humidification granules: pass the soft material prepared in (2) through a 20-mesh sieve to make granules.

[0061] (4) Drying: Dry the wet granules prepared in (3) at a temperature of 50-70° C. for 20-120 minutes until the water content of the granules is 2-4%.

[0062] (5) Grain sizing: Pass the dry granules prepared in (4) through a 40-mesh sieve. spare.

[0063] (6) Blending: Add 21% microcrystalline cellulose and 0.5% magnesium stearate to the dry granules after (5) granulation for blending.

[0064] (...

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Abstract

The present invention relates to the field of health food processing, and in particular relates to a compound tablet with a high content of chondroitin sulfate and a preparation method thereof. The present invention provides a portable swallow tablet with a high content of chondroitin sulfate which has significant functions and effects. According to the present invention, after optimization of the formula and the preparation method, problems that the disintegration of swallow tablets with a high content of chondroitin sulfate is difficult, and because of too much addition of disintegrating agents, coating of the tablets is prone to pitting, or disintegrating tablets may be produced in storing process. Further, compatibility of the products of the present invention and vitamin K is studied and vitamin K is added in the product, thereby enhancing effectiveness of the product. The coated tablets of the present invention has smooth surface, stable quality, good moisture resistance, and more significant functions and effects.

Description

technical field [0001] The invention relates to the field of health food, in particular to a high-content chondroitin sulfate composite tablet and a preparation method thereof. Background technique [0002] Chondroitin sulfate is a natural acidic mucopolysaccharide extracted from animal tissues. Chondroitin sulfate is a kind of glycosaminoglycan, composed of D-glucuronic acid and N-acetylgalactosamine in the form of β - Polysaccharides composed of repeating disaccharide units connected by 1,4-glycosidic bonds, and sulfated on the C-4 or C-6 hydroxyl of N-acetylgalactosamine. [0003] Chondroitin sulfate is the main component of articular cartilage, which can promote bone growth, repair bone tissue, supply nutrients needed for bone growth, participate in bone metabolism, and is mainly used for osteoarthritis, bone density increase and other diseases. According to research, the loss of chondroitin sulfate is one of the main causes of osteoarthritis. The physiological functio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A23L1/09
Inventor 刘勇李文霞赵耘李健上官海燕吴国卿毛岳忠王青标郭脉玺柏金霞高靳磊
Owner 杭州海王生物工程有限公司
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