Continuous preparation system and preparation method for fullerene derivatives

Abstract

The invention provides a continuous preparation system and a preparation method for fullerene derivatives. The continuous preparation system for the fullerene derivatives comprises a synthetic reaction device, an extraction reaction device, a vacuum distillation device, a filtering reaction device, a chromatographic separation device and a collection device which are communicated with each other in sequence; and the continuous preparation system also comprises a vacuum pump, an air filling pump, a first reagent bottle, a second reagent bottle, a third reagent bottle, a fourth reagent bottle and a waste fluid bottle, wherein the communication between parts is controlled by valves. The continuous preparation system provided by the invention can be used for continuously preparing the fullerene derivatives on a large scale under an airtight and pollution-free condition till the pure product is packaged, subsidiary devices can be increased or decreased according to actual needs to change a preparation process, and the continuous preparation system is a device for synthesizing the fullerene derivatives with a wide application scope.

Description

technical field [0001] The invention relates to the preparation of fullerene derivatives, in particular to a continuous preparation system and method for fullerene derivatives. Background technique [0002] Fullerene derivatives have excellent properties and are widely used in many fields. For example, in the field of biomedicine, pure fullerene has extremely poor water solubility, so that it not only cannot fully exert its good biological effects, but has some negative effects . Water-soluble fullerene derivatives, such as fullerene polyhydroxy derivatives, carboxyl derivatives, sulfonic acid derivatives, etc., have improved their biocompatibility through the introduction of hydrophilic functional groups, and all show good biological effects. . Years of research have shown that these derivatives have good application prospects in MRI contrast agents, antitumor drugs, radiopharmaceuticals, anti-HIV viruses, free radical scavengers, and drug delivery. In the field of energ...

AI Technical Summary

Problems solved by technology

This makes the reproducibility of the preparation process poor, and there are differences in the properties of the finished products prepared by different laboratories or even different batches, and the workload is heavy, which is not conducive to large-scale production, which limits the development and application of this product

Especially if it is applied in the field of biomedicine, this discrete preparation method will also cause cross-contamination in the material preparation process, causing problems such as bacterial growth, which must be avoided in biomedical applications

[0004] At present, there are problems in the preparation of fullerene derivatives: 1) The preparation is in the laboratory stage, and the whole preparation process requires multiple instruments to complete, and the instruments are separated, and the whole process is discontinuous and not airtight

2) The organic reagents in the experiment will pollute the surrounding environment and operators, and the samples will also be polluted by the external environment

3) The human factors in the preparation process are greatly affected, and the control accuracy of each step is not enough, which makes the product properties and yield reproducibility poor

4) Due to the complicated process, the workload of the operator is heavy

Images