Detection method for Cinnamomum migao heart-comforting preparation

A detection method and preparation technology, which is applied in the detection field of traditional Chinese medicine preparations, can solve problems affecting product production, hidden dangers of product quality, etc., and achieve the effect of ensuring advancedness, method specificity, and good reproducibility

Active Publication Date: 2013-05-15
GUIZHOU YIBAI PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In further research, we found that in the prescription of Migao Xinle Dropping Pills, the proportion of Ligusticum chuanxiong is relatively large, which is second only to the content of Daguomu Jiangzi in the main drug. Failure to measure the content of Rhizoma Chuanxiong in the prescription will affect the production of the product and cause hidden dangers to the product quality

Method used

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  • Detection method for Cinnamomum migao heart-comforting preparation
  • Detection method for Cinnamomum migao heart-comforting preparation
  • Detection method for Cinnamomum migao heart-comforting preparation

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Embodiment 1

[0112] The detection method of embodiment 1 Migao Xinle dripping pills

[0113] Take 4500g of Daguomu Jiangzi, 90g of Ai Pian, 3600g of Ligusticum Chuanxiong, 360g of Allium scallion, the above four flavors, and extract the volatile oil of Daguomu Jiangzi with steam distillation, and set aside. Ligusticum chuanxiong is broken, add ethanol and reflux extraction twice, the first time 6 times the amount of immersion for 2 hours, reflux extraction for 3 hours, the second time 4 times the amount, reflux extraction for 2 hours, filter, combine the filtrates, recover ethanol under reduced pressure and concentrate to The relative density is 1.05-1.15 under the condition of 55-60°C, let it stand still and let it be divided into three layers, take the middle layer liquid and concentrate it under reduced pressure to the relative density of 1.10-1.20 under the condition of 55-60°C, adjust the pH to 9-10 with concentrated ammonia water , extracted three times with chloroform, 3 times the a...

Embodiment 2

[0142] The detection method of embodiment 2 Migao Xinle Oral Liquid

[0143] Take 4500g of Daguomu Jiangzi, 90g of Ai Pian (Levoborneol), 3600g of Rhizoma Chuanxiong, 360g of Allium scallion, the above four flavors, and extract the volatile oil of Daguomu Jiangzi with steam distillation, and set aside. Ligusticum chuanxiong is broken, add ethanol and reflux extraction twice, the first time 6 times the amount of immersion for 2 hours, reflux extraction for 3 hours, the second time 4 times the amount, reflux extraction for 2 hours, filter, combine the filtrates, recover ethanol under reduced pressure and concentrate to The relative density is 1.05~1.15 (55~60°C), let it stand still and let it be divided into three layers, take the middle layer liquid and concentrate it under reduced pressure to a relative density of 1.10~1.20 (55~60°C), adjust the pH to 9~10 with concentrated ammonia water , extracted three times with chloroform, 3 times the amount for the first time, 2 times th...

Embodiment 3

[0172] The detection method of embodiment 3 Migao Xinle syrup

[0173] Take 4500g of Daguomu Jiangzi, 90g of Ai Pian (Levoborneol), 3600g of Rhizoma Chuanxiong, 360g of Allium scallion, the above four flavors, and extract the volatile oil of Daguomu Jiangzi with steam distillation, and set aside. Ligusticum chuanxiong is broken, add ethanol and reflux extraction twice, the first time 6 times the amount of immersion for 2 hours, reflux extraction for 3 hours, the second time 4 times the amount, reflux extraction for 2 hours, filter, combine the filtrates, recover ethanol under reduced pressure and concentrate to The relative density is 1.05~1.15 (55~60°C), let it stand still and let it be divided into three layers, take the middle layer liquid and concentrate it under reduced pressure to a relative density of 1.10~1.20 (55~60°C), adjust the pH to 9~10 with concentrated ammonia water , extracted three times with chloroform, 3 times the amount for the first time, 2 times the amou...

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Abstract

The invention discloses a detection method for a Cinnamomum migao heart-comforting preparation. The Cinnamomum migao heart-comforting preparation is prepared from the following drugs by weight: 3500-6000 parts of Cinnamomum migao, 40-150 parts of borneol, 2500-5000 parts of Ligusticum wallichii, and 250-500 parts of Allium macrostemon. The method provided in the invention takes a ferulic acid reference sample for reference, and adopts methanol-acetonitrile-0.1% phosphoric acid as a mobile phase to determine the content of Ligusticum wallichii in the product, with the methanol, the acetonitrile and the 0.1% phosphoric acid being in a volume ratio of 15:10:75. Compared with the prior art, the method has the characteristics of specificity, feasibility and good reproducibility, and can effectively control the quality of the Cinnamomum migao heart-comforting dropping pill preparation. Repeated tests confirm that the detection method has the advantages of stability, simplicity, accurate result as well as good reproducibility, so that the method can be used as a detection method for Cinnamomum migao heart-comforting dropping pills, oral liquids, syrups, granules, freeze-dried powder injections, and can be taken as an index for inspecting the technological stability.

Description

technical field [0001] The invention relates to a detection method of a traditional Chinese medicine preparation, in particular to a detection method of a Migaoxinle preparation. Background technique [0002] Migao Xinle Dropping Pill is a medicine that is commonly used by the Miao people in Guizhou Province to treat chest pain and heart pain. It is formulated according to the Miao people's medication habits and TCM theory. The traditional Chinese medicine preparation has the effects of aroma, warming, regulating qi and relieving pain. It is mainly used to treat chest pain and heart pain (angina pectoris due to coronary heart disease) caused by condensed yin and cold, and loss of warm qi. Cold pain, poor breathing, etc. It has been used clinically to prevent and treat yin-cold stagnation type chest pain and heart pain, and has achieved good results. [0003] In the prior art, for the quality detection method of Migao Xinle dripping pills, Chinese patent application CN10170...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/90
Inventor 窦啟玲卫江明邓思雄
Owner GUIZHOU YIBAI PHARMA CO LTD
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