High molecular porous material with surface deposited bone-like hydroxyapatite as well as preparation method and application thereof
A technology of polymer materials and porous materials, applied in the field of polymer porous materials deposited on the surface of bone-like apatite and its preparation, can solve the problems of unstable interface bonding, easy to fall off, and difficult to achieve internal pore wall modification, etc., to achieve Good biocompatibility and tissue induction, solve the problem of interface binding, simple and convenient preparation process
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Embodiment 1
[0027] Polyglycolide-lactide porous materials were prepared by particle pore-forming technology. Dissolve 2 g of polyglycolide lactide with a molecular weight of 500,000 in 10 mL of dichloromethane, add 25 g of pre-screened 200-300 μm sodium chloride particles, mix well and fill it into a mold, the inner diameter of the mold is 12 mm and 15 mm in height, the sample was taken out after being kept under pressure for 1 day at room temperature, and the salt porogen was washed away with deionized water. Material.
[0028] For plasma treatment, the gas atmosphere is oxygen, the gas pressure is 8 Pa, the plasma power is 50 W, the plasma treatment time is 20 minutes, and the oxygen atmosphere condition is maintained for 5 minutes.
[0029] Prepare high-concentration simulated body fluids with deionized water with 2000 mmol / L sodium ions, 50 mmol / L potassium ions, 50 mmol / L calcium ions, 50 mmol / L magnesium ions, and 50 mmol / L phosphate ions. The filter membrane filters impurities an...
Embodiment 2
[0033] The preparation process of the porous material is the same as in Example 1. The difference is that polyglycolide lactide with a molecular weight of 750,000 and sodium chloride particles of 50-200 μm are selected, and after drying, polyglycolide-lactide with a pore size of 50-200 μm and a porosity of about 90% is obtained. porous material.
[0034]For plasma treatment, the gas atmosphere is oxygen, the gas pressure is 8 Pa, the plasma power is 50 W, the plasma treatment time is 15 minutes, and the oxygen atmosphere condition is maintained for 5 minutes. Then the material was immersed in 5 mol / L hydrochloric acid solution for 5 minutes, and then washed with deionized water.
[0035] High-concentration simulated body fluids were prepared with deionized water with 1000 mmol / L of sodium ions, 25 mmol / L of potassium ions, 25 mmol / L of calcium ions, 25 mmol / L of magnesium ions, and 25 mmol / L of phosphate ions. The filter membrane filters impurities and adjusts the pH between...
Embodiment 3
[0039] The preparation process of the porous material is the same as in Example 1. The difference is that polyglycolide lactide with a molecular weight of 1 million and sodium chloride particles of 300-450 μm are selected, and after drying, polyglycolide lactide with a pore size of 300-450 μm and a porosity of about 90% is obtained. porous material.
[0040] For plasma treatment, the gas atmosphere is oxygen, the gas pressure is 8 Pa, the plasma power is 50 W, the plasma treatment time is 15 minutes, and the oxygen atmosphere condition is maintained for 5 minutes. Then the material was immersed in 5 mol / L sodium hydroxide solution for 1 minute, and then washed with deionized water.
[0041] Prepare high-concentration simulated body fluids with deionized water with 800 mmol / L sodium ions, 20 mmol / L potassium ions, 20 mmol / L calcium ions, 20 mmol / L magnesium ions, and 20 mmol / L phosphate ions. The filter membrane filters out impurities and adjusts the pH between 3 and 4.
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