Novel technology for extracting high purity heparin sodium from intestinal mucosa
A technology of heparin sodium and intestinal mucosa, applied in the field of bioengineering, can solve the problems of high cost, complex production process, no mention of removal methods, etc., and achieve the effect of improving the recovery rate
Inactive Publication Date: 2013-06-05
RUGAO YONGXING CASING
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The above method is a typical industrial process for preparing and purifying heparin sodium, the production process is complex and the cos...
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The invention relates to a preparation and purification method for biological medicinal raw material, belonging to the field of bioengineering, and in particular relates to a technology for preparing high purity low molecular heparin sodium. The method aims at overcoming the defects of the prior art. The invention provides a convenient technology for preparing and purifying low molecular heparin sodium. The average molecular mass of the prepared low molecular heparin sodium is about 4.5KDa, the titer of the prepared low molecular heparin sodium is not lower than 180U/mg and is higher than 170U/mg required in Chinese pharmacopoeia, and the prepared low molecular heparin sodium is up to standard according to the test standard of the heparin sodium in the Chinese pharmacopoeia.
Description
technical field [0001] The invention relates to a method for preparing and purifying biomedicine raw materials, which belongs to the field of bioengineering, in particular to a process for preparing high-purity low-molecular-weight heparin sodium. Background technique [0002] Heparin sodium is an anion-rich mucopolysaccharide sulfate, which is produced by mast cells and basophils in animals. It is originally extracted from the liver, so it is named heparin. Clinically used heparin is a sodium (lithium) salt extracted from animal intestines, lung mucosa, and blood vessel walls. Heparin sodium (lithium) has various biological functions such as anticoagulation, anti-inflammation, and anti-cancer, but long-term use There will be side effects such as bleeding and fractures. In the early 1980s, it was found that low molecular weight heparin sodium (LMWH, (8000Da) has stronger activity and less side effects, and has become the main clinical anticoagulant drug. [0003]...
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Inventor 费苹陈银芳费正明陈明全
Owner RUGAO YONGXING CASING
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