Triamcinolone biodegradable maltose microneedle array and preparation method thereof

A technology of microneedle array and triamcinolone acetonide, which can be used in drug delivery, drug combination, and pharmaceutical formulation, and can solve problems such as unbearable pain, imbalance, and multi-point injection

Inactive Publication Date: 2013-07-03
SHANGHAI SEVENTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the difficulty in absorption of surface coating administration, and the disadvantages of intra-scar injection administration such as unbearable pain, multi-point injection, inaccurate or uneven dosage, there is currently no pharmaceutical dosage form that is very suitable for the treatment of scars.

Method used

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  • Triamcinolone biodegradable maltose microneedle array and preparation method thereof
  • Triamcinolone biodegradable maltose microneedle array and preparation method thereof
  • Triamcinolone biodegradable maltose microneedle array and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1 Preparation of triamcinolone acetonide biodegradable maltose microneedle array by stepwise controlled pulling method

[0083] (1) Dissolve 10 mg of commercially available maltose powder and 10 μL of deionized water at 110°C for 10 min, then spread the liquid maltose on a circular stainless steel substrate, and quickly add 1 mg of triamcinolone acetonide (Tianjin Pacific Chemical Pharmaceutical Co., Ltd.) powder , mix evenly, cool down to 103°C and spread the mixture to a thickness of 122±13.5μm.

[0084] (2) Put the prepared stainless steel column frame (such as figure 1 shown) adhered to the spread maltose, and microneedles with different needle shapes could be prepared according to pulling the maltose at different temperatures.

[0085] (3) a. Baseball rod-shaped microneedles: Control the temperature at 100°C, when the maltose matrix is ​​in a glass state, pull the maltose at a speed of 400μm / s for 3s, cool down to 60°C, cool and solidify the microneedles, ...

Embodiment 2

[0088] Example 2 Preparation of triamcinolone acetonide biodegradable maltose microneedle array by micromolding method

[0089] (1) Dissolve 10 mg maltose and 10 μL deionized at 110° C. for 10 min, then add 1 mg powdered triamcinolone acetonide and mix well.

[0090] (2) Pour the liquid mixture into a conical mold, cover with a 300g stainless steel plate, and cool slowly to make it solidify. The steel plate is then removed, separating the solid microneedles from the mold.

Embodiment 3

[0091] Example 3 Pain Sensation Experiment of Triamcinolone Maltose Microneedle Array

[0092] (1) Case source: 12 scar patients, aged 22-53 years, with an average age of (37.59±8.04) years, including 6 males and 6 females.

[0093] (2) Administration method: local injection of triamcinolone acetonide injection and triamcinolone acetonide maltose microneedle array administration respectively.

[0094] (3) The patient's pain score standard is shown in Table 1:

[0095] Table 1

[0096] It's a sharp pain

more painful

pain

a little pain

painless

10-8

8-6

6-4

4-2

2-0

[0097] (4) Statistical method

[0098] The data are represented by mean ± standard deviation (x ± SD), and the statistical analysis is carried out with SAS6.12 statistical analysis software, and the data of different administration methods are analyzed by paired t test, and P<0.01 means that the difference is statistically significant.

[0099] (...

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Abstract

The invention relates to a triamcinolone biodegradable maltose microneedle array and a preparation method thereof. Concretely, the invention provides a microneedle array and a preparation method thereof, wherein a microneedle comprises: (1) triamcinolone or its pharmaceutically acceptable salt, and (2) maltose or a hydrate thereof. The length of the microneedle is 800-1500mum. The triamcinolone biodegradable maltose microneedle array has advantages of long drug effect time, uniform absorption, easy absorption, painless feeling when dosing.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, and relates to a triamcinolone acetonide biodegradable maltose microneedle array and a preparation method thereof. Background technique [0002] Scar is a general term for the appearance, morphology and histopathological changes of normal skin tissue caused by various traumas. sound organization. Scars not only destroy the beauty of the body surface, but also hinder the physiological functions of related tissues or organs, and even lead to deformities. It is easy to bring long-term physical and mental damage, and seriously affects the normal work and life of patients. [0003] Among the scar treatment methods commonly used at present, local drug treatment (such as surface coating administration or intra-scar injection administration) is a relatively common method. However, due to the difficulty in absorption of surface coating administration, and the disadvantages of intra-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/58A61K47/26A61P17/02
Inventor 张立超吴志宏
Owner SHANGHAI SEVENTH PEOPLES HOSPITAL
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