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Preparation method of multifunctional eccentric mesoporous silica core-shell nanoparticles

A technology of mesoporous silica and nanoparticles, which can be applied to preparations for in vivo tests, medical preparations with inactive ingredients, and pharmaceutical formulas, etc. The effect of stability, high drug loading and convenient operation

Inactive Publication Date: 2014-10-01
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] So far, there is no report on the combination of mesoporous silica and pH-responsive controlled drug delivery system to form eccentric mesoporous Multifunctional nanoparticles of silica, and only one template is used as both a mesoporous generator and a pH-responsive controlled drug delivery system, thereby reducing complex surface modification and post-processing processes

Method used

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  • Preparation method of multifunctional eccentric mesoporous silica core-shell nanoparticles
  • Preparation method of multifunctional eccentric mesoporous silica core-shell nanoparticles
  • Preparation method of multifunctional eccentric mesoporous silica core-shell nanoparticles

Examples

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Embodiment 1

[0035] Preparation of 80 nm fluorescence-labeled eccentric mesoporous silica-wrapped PAA and Fe3O4 core-shell nanoparticles:

[0036] (1) Synthesis of CTAB-protected Fe3O4 nanoparticles: take 500 μL, 10 mg mL -1 Oleic acid-protected 25 nm Fe3O4 nanoparticles dissolved in chloroform were mixed with 10 mL of 0.2 M CTAB and vigorously stirred at 32 °C for 30 min. Then the solution was warmed up to 60 oC to evaporate the organic solvent chloroform, kept stirring for 20 minutes and then cooled to room temperature. The excess CTAB molecules were washed twice with deionized water and centrifuged to collect CTAB-protected Fe3O4 nanoparticles.

[0037] (2) Preparation of eccentric PAA-coated Fe3O4 core-shell nanoparticles: Take the CTAB-protected Fe3O4 nanoparticles prepared in step (1) and add 5 mL of deionized water for ultrasonic dispersion. Add 40 μL PAA aqueous solution (0.2 g mL -1 ) and 60 μL NH 3 ·H 2 O solution (2 M), sonicate for half an hour each time. Then 120 mL of i...

Embodiment 2

[0040] Preparation of 100 nm fluorescence-labeled eccentric mesoporous silica-coated PAA and Fe3O4 core-shell nanoparticles:

[0041] (1) Synthesis of CTAB-protected ferric oxide nanoparticles: the specific operation is the same as step (1) in Example 1.

[0042] (2) Preparation of eccentric PAA-wrapped ferric oxide core-shell nanoparticles: the specific operation is the same as step (2) in Example 1.

[0043](3) Preparation of 100 nm fluorescence-labeled eccentric mesoporous silica-wrapped PAA and Fe3O4 core-shell nanoparticles: Take 15 mL of eccentric PAA-wrapped Fe3O4 core-shell nanoparticles prepared in step (2), Join 2 MNH 3 ·H 2 O solution to adjust the pH of the solution to 8, and then add 5 μL of FITC-silane precursor and 500 μL of 20% isopropanol solution of tetrahexyl orthosilicate (TEOS), wherein the isopropanol solution of TEOS was added every 30 min Add once and add in seven times. Then, the mixed solution was continuously stirred at room temperature for 24 h....

Embodiment 3

[0045] Preparation of 130 nm fluorescence-labeled eccentric mesoporous silica-wrapped PAA and Fe3O4 core-shell nanoparticles:

[0046] (1) Synthesis of CTAB-protected ferric oxide nanoparticles: the specific operation is the same as step (1) in Example 1.

[0047] (2) Preparation of eccentric PAA-wrapped ferric oxide core-shell nanoparticles: the specific operation is the same as step (2) in Example 1.

[0048] (3) Preparation of 130 nm fluorescence-labeled eccentric mesoporous silica-wrapped PAA and Fe3O4 core-shell nanoparticles: Take 15 mL of eccentric PAA-wrapped Fe3O4 core-shell nanoparticles prepared in step (2), Join 2 MNH 3 ·H 2 O solution to adjust the pH of the solution to 8, then add 5 μL of FITC-silane precursor and 750 μL of 20% isopropanol solution of tetrahexyl orthosilicate (TEOS), wherein the isopropanol solution of TEOS was added every 30 min Add once and add ten times. Then, the mixed solution was continuously stirred at room temperature for 24 h. After...

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Abstract

The invention belongs to the technical field of nanocomposite materials, and in particular relates to a preparation method of multifunctional eccentric mesoporous silica core-shell nanoparticles. While generating eccentric mesoporous silica nanoclusters on the PAA template, PAA chains with pH-responsive control drug delivery capabilities are also embedded inside, avoiding the subsequent process of processing the template PAA and modifying the pH-responsive polymer. , endowed mesoporous silica nanoparticles with pH-responsive controlled drug delivery capabilities. Through this method, the present invention prepares a series of multifunctional nanoparticles with novel mesoporous silica nanoclusters covering eccentric functional cores and PAA chains. The method of the invention is novel, general, mild, easy to operate, and the obtained nano particles have unique structure, good dispersibility, complete functions, less toxic and side effects, and have wide application prospects in multiple fields such as biological treatment and clinical medicine.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and in particular relates to a preparation method of multifunctional eccentric mesoporous silica core-shell nanoparticles. Background technique [0002] Recently, multifunctional nanomaterials formed by encapsulating different types of functional nanoparticles in mesoporous silica have attracted extensive attention in multimodal imaging and point-of-care diagnosis and treatment. Using mesoporous silica as a matrix, different functional components such as magnetic, upconverting, plasmonic nanoparticles, quantum dots, and fluorescent molecules are embedded in it to form a central multifunctional core-shell nanocomponent, and in the The unique functions of the various components are maintained when used as delivery vehicles, enabling magnetic resonance and fluorescence imaging and the ability to deliver anticancer drugs to tumor sites. Among them, by combining imaging and drug deliv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/32A61K47/04A61K47/02A61K49/00
Inventor 王婷婷陈露露李鹿张凌宇
Owner CHANGCHUN UNIV OF SCI & TECH
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