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Apparatus for extracorporeal blood treatment

A technology of extracorporeal blood treatment and measuring devices, which is applied in the direction of pharmaceutical devices, other medical devices, suction devices, etc., and can solve problems such as the inability to distinguish uremic toxins and the inability to test the dialysis effect of dialysate

Active Publication Date: 2013-07-31
B BRAUN ETHERNET AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage, however, is that until now there was no way to distinguish uremic toxins from used dialysate and thus to test the dialysis effect of the dialysate of the dialysis machine or the components of the dialysis machine involved in blood purification.

Method used

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  • Apparatus for extracorporeal blood treatment
  • Apparatus for extracorporeal blood treatment
  • Apparatus for extracorporeal blood treatment

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0148] Dialysate samples from dialysis patients were drawn 10 minutes after treatment initiation and measured spectrophotometrically Absorbance in the wavelength range. In the present case, the absorbance is negligible for wavelengths greater than λ = 340 nm. In the range of λ=340 nm to λ=290 nm, the absorbance first rises sharply, then remains stable up to about λ=260 nm, and then rises sharply again. A local maximum is visible at λ=230nm. When the wavelength is less than λ=220nm, a further increase in absorbance can be observed. The dialysate spectra of different patients are generally distinguished from one another by their intensity and absorbance curves in the range between λ=290 nm to λ=255 nm. In the shown figures the curve in this range remains essentially constant, however local minima (e.g. A λ=260nm =0.5) or a strictly monotonically increasing function (such as A λ=260nm =1.5). figure 1 The spectrum of a dialysate sample of dialysate effluent from a dialysis ...

example 2

[0150] The absorption properties of uric acid at a concentration c=1 mg / l were determined spectrophotometrically in water for a wavelength range of 200 to 400 nm. figure 2 Qualitatively illustrate the absorption characteristics of uric acid in the range of λ=400nm to λ=200nm. Three local maxima at λ=290nm, λ=235nm and λ=205nm are clearly visible, among which the maximum absorbance (A λ=205nm =1.5 or A λ=290nm =0.7).

example 3

[0152] The absorption properties of malondialdehyde at a concentration c=1 mg / l were determined spectrophotometrically in water for a wavelength range from 200 to 400 nm. image 3 Qualitatively illustrate the absorption characteristics of malondialdehyde in the range of λ=400nm to λ=200nm. The local maximum at λ=266nm is clearly visible (A λ=266nm =1.005).

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Abstract

The invention describes an apparatus for extracorporeal blood treatment, with a dialyser that is divided by a semipermeable membrane into a first chamber and second chamber (29, 30), wherein the first chamber (29) is arranged in a dialysis liquid path and the second chamber (30) can be connected to the blood circulation of a patient by way of a blood delivery line (32) and a blood removal line (31), with an inlet (20) for fresh dialysis liquid, an outlet (36) for used dialysis liquid, and a measurement device (37) arranged in the outlet (36), wherein the measurement device (37) has at least one radiation source consisting of a plurality of light sources (1) for electromagnetic radiation. The invention is characterized in that the measurement device (37) is designed to generate substantially monochromatic electromagnetic radiation of different wavelengths and in each case to convey only one of these wavelengths (at the same time) through the outlet (36) for used dialysis liquid, wherein at least one detector system (5) is provided for detecting the intensity or absorbance of the substantially monochromatic electromagnetic radiation passing through the outlet (36) for used dialysis liquid.

Description

technical field [0001] The present invention relates to a device for extracorporeal blood treatment for differentiating uremic toxins in the effluent from the device. Background technique [0002] For patients with renal insufficiency or loss through renal replacement therapy or dialysis, the waste products of natural substance metabolism, including uremic toxins, are removed. In this case, the substances are removed from the blood by bringing blood drawn from the patient and conducted outside the body into contact with a dialysate, the blood and the dialysate not being in direct contact, but being able to contact each other through a membrane. The dialysate is mixed with various salts so as to cause diffusion and convective effects which are responsible for the transport of substances from the blood to the dialysate via membranes arranged outside the body. After a portion of the waste is removed, the processed blood is reinfused into the patient. [0003] For testing the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16
CPCA61M1/14A61M2202/0498A61M1/16A61M2001/1609G01N21/33A61M2001/1613A61M2205/3313A61M1/1609A61M1/1613A61M2205/52A61M2205/3306A61M1/361A61M1/3612
Inventor J·迈鲍姆S·莫尔A·卡斯特利亚尔瑙
Owner B BRAUN ETHERNET AG
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