Mechanics loading type bioreactor capable of carrying out online measurement
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A bioreactor and mechanical technology, applied in the mechanical loading bioreactor constructed by bone tissue, in the field of cartilage in vitro, can solve problems such as poor mechanical strength, and achieve the effect of simple operation, strong practicability, and timely and accurate control response.
Inactive Publication Date: 2013-08-28
HARBIN INST OF TECH
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[0005] The present invention aims to solve the problem of poor mechanical strength in artificial cartilage and bone tissue in vitro con
Method used
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specific Embodiment approach 1
[0019] Specific implementation mode one: as figure 1 and figure 2 As shown, the mechanically loaded bioreactor that can be measured online in this embodiment includes a base 1, a support shaft 2, a rack and pinion mechanism 3, a weight sensor 4, a culture platform 5, a pressure head 6, a bacteria isolation loading platform 7, a test Sheet 8, connector 9, displacement sensor 10, piezoelectric ceramic micro-displacement brake 11, first support disc 12, locking device 13, stud 14, spiral outer sleeve 15, spiral inner sleeve 24, cylindrical spring 25, guide cylinder 17. The second support disc 18, turntable 20, cover cup 21, stepper motor 22, three sleeves 16, three support rods 19 and three correction flanges 23, the rack and pinion mechanism 3 is fixed by the support shaft 2 Installed on the upper end surface of the base 1, the lower end of each support rod 19 is fixed on the upper end surface of the base 1 through a rectification flange 23, and the three support rods 19 are e...
specific Embodiment approach 2
[0030] Specific implementation mode two: as figure 1 As shown, the stud 14 of this embodiment is made of brass. This design reduces the friction between the stud and the inner and outer shell of the screw, which is convenient for operation. Other components and connections are the same as those in the first embodiment.
specific Embodiment approach 3
[0031] Specific implementation mode three: as figure 1 As shown, the support rod 19 of this embodiment is made of stainless steel. So designed to avoid rust. Other compositions and connections are the same as those in Embodiment 1 or 2.
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Abstract
The invention discloses a mechanics loading type bioreactor capable of carrying out online measurement, and relates to a mechanics loading type bioreactor which solves the problem of poor mechanical strength during in vitro construction of artificial cartilages and bone tissues of an existing mechanics loading type bioreactor. The lower end faces of sleeves are positioned on the upper end face of a second support disc, a first support disc is fixed on the upper end faces of three sleeves, a first center hole is formed in the first support disc, a screw jacket is fixedly arranged at the center hole of the first support disc, a second center hole is formed in the second support disc, a guide cylinder is fixedly arranged at the second center hole, the lower end of a piezoelectric ceramics micrometric displacement brake sequentially passes through the center holes of the first support disc and the second support disc, the upper part of the piezoelectric ceramics micrometric displacement brake is fixed and located by the screw jacket and the guide cylinder, the lower end of the piezoelectric ceramics micrometric displacement brake is fixedly connected with a test piece through a connecting member, and a bacterium-isolating loading platform is fixedly arranged on the lower end face of the test piece. The mechanics loading type bioreactor is used for constructing the artificial cartilages and the bone tissues.
Description
technical field [0001] The invention relates to a mechanically loaded bioreactor capable of on-line measurement, in particular to a mechanically loaded bioreactor for in vitro cartilage and bone tissue construction. Background technique [0002] Trauma, degeneration, or certain osteoarthritis diseases often cause mobility impairment, which can lead to complete loss of joint function in severe cases, which is very common in clinical practice. For cartilage defects, traditional treatment methods have long been difficult to achieve satisfactory clinical results. In addition, with the advancement of society and the arrival of an aging society, the incidence of cartilage and bone diseases is increasing year by year. There are more than ten million such patients worldwide, which results in an increasing demand for cartilage and bone tissue repair and replacement. It's getting bigger and bigger. [0003] At present, the in vitro cartilage and bone tissue construction technology m...
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