Evodiamine nanoemulsion

A technology of evodial alkaloid and nanoemulsion, which is applied in the directions of emulsion delivery, organic active ingredients, medical preparations containing active ingredients, etc. Targeting, tumor-inhibiting effect, and apoptosis-promoting effect

Active Publication Date: 2013-09-11
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of studies at home and abroad have shown that evodiamine has pharmacological activities such as dilating blood vessels, anti-inflammation, analgesia, weight loss, regulating body temperature, anti-tumor, and inhibiting cancer cell metastasis. It has broad development prospects, but the water solubility of evodiamine is extremely poor. The bioavailability after administration is very low, and it has been reported in the literature that its oral bioavailability in rats is only 0.1%. Although evodiamine has various pharmacological activities, it needs to be improved

Method used

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  • Evodiamine nanoemulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The percentage by weight of each component contained in the prescription consists of:

[0015]

[0016] The preparation method adopts the high-pressure emulsification method, which includes the following steps: mix the oil phase (ethyl oleate), CremorphorEL35 and polyethylene glycol 400 in the prescribed amount, add the evodiamine and the water phase in the prescribed amount, stir to obtain colostrum, and then Pass through the high pressure homogenizer 6 times.

Embodiment 2

[0018] The percentage by weight of each component contained in the prescription consists of:

[0019]

[0020] The preparation method adopts the water titration method, comprising the following steps: the oil phase (mixture of ethyl oleate and Brucea javanica oil), Cremorphor EL 35 and Polyethylene Glycol 400 are mixed evenly, and after adding the evodiamine of the prescription amount and stirring, Add the prescribed amount of water dropwise with vortexing.

Embodiment 3

[0022] The percentage by weight of each component contained in the prescription consists of:

[0023]

[0024] The preparation method adopts the high-pressure emulsification method, which includes the following steps: mix the oil phase (mixture of ethyl oleate and javanica javanica oil), Cremorphor EL 35 and polyethylene glycol 400 in the prescribed amount, and then add evodiamine and water in the prescribed amount Phase, stir to obtain colostrum, and then pass through the high-pressure homogenizer 3 times.

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Abstract

The invention belongs to the field of pharmaceutic preparations, and relates to a formula and a preparation method of an evodiamine nanoemulsion. The evodiamine nanoemulsion prepared by the invention can be used for improving the solubility of medicines and enhancing the bioavailability and the pharmacological activity.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to evodiamine nanoemulsion and a preparation method thereof. Background technique [0002] Evodia rutaecarpa (Juss.) Benth., Shihu Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang or Shu. Dry near-ripe fruit of Evodia rutaecarpa (Juss.) Benth.var.bodinieri (Dode) Huang. Evodiamine (EVO) is the main alkaloid in this plant. A large number of studies at home and abroad have shown that evodiamine has pharmacological activities such as dilating blood vessels, anti-inflammation, analgesia, weight loss, regulating body temperature, anti-tumor, and inhibiting cancer cell metastasis. It has broad development prospects, but the water solubility of evodiamine is extremely poor. The bioavailability after administration is very low, and it has been reported in the literature that its oral bioavailability in rats is only 0.1%. Although evodiamine has various pharmacologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/519A61P35/00
Inventor 张景勍谭群友何丹柳珊
Owner CHONGQING MEDICAL UNIVERSITY
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