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Andrographis paniculata hand sanitizer and preparation method thereof

A technology of Andrographis paniculata and hand sanitizer, which is applied in the directions of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc. It can solve the problems that the application of Andrographis paniculata is still blank, and achieve good thickening effect, no skin irritation, and excellent foam stabilization performance. Effect

Inactive Publication Date: 2013-09-18
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are as many as dozens of preparations made from Andrographis paniculata extract or andrographolide and its derivatives on the market, among which injections, tablets, capsules, etc. are the most widely used. Application is blank

Method used

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  • Andrographis paniculata hand sanitizer and preparation method thereof
  • Andrographis paniculata hand sanitizer and preparation method thereof
  • Andrographis paniculata hand sanitizer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0028] The preparation of embodiment 1-5 Andrographis paniculata hand sanitizer

[0029] Table 1 embodiment 1-5 and the formula table of each hand sanitizer of comparative example 1-2

[0030]

[0031]

[0032] Taking Example 1 as an example to describe the Andrographis paniculata hand sanitizer preparation technology in detail, comprising the following steps:

[0033] (1) Weigh 40 parts of MES, add 30 parts of distilled water, stir until completely dissolved and dispersed to obtain solution a;

[0034] (2) Weigh 0.5 parts of andrographis paniculata extract, 2 parts of propylene glycol, and 10 parts of glycerin, stir (properly heat) to dissolve, and obtain solution b;

[0035] (3) Mix solution a and solution b evenly, add 12 parts of distilled water and 1 part of essence, and stir evenly;

[0036] (4) Weigh 4.5 parts of sodium chloride, add it into the solution obtained in step (3) while stirring, and stir evenly to obtain Andrographis paniculata hand sanitizer.

[00...

Embodiment 6

[0040] Example 6 External Drug Sensitivity Test of Andrographis paniculata Handwashing Liquid

[0041] 1 Experimental materials

[0042] 1.1 Experimental equipment

[0043] Single-person double-sided purification workbench (Suzhou Purification Equipment Co., Ltd.), high-pressure steam sterilizer (Shanghai Sanshen Medical Instrument Co., Ltd.), constant temperature incubator (Ikemoto Chemical Industry Co., Ltd.), air bath oscillator (Harbin Donglian Electronic Technology Development Co., Ltd.), pipette gun, 9cm glass petri dish, 10ml test tube with silicone stopper, Erlenmeyer flask with silicone stopper (250ml and 500ml) and test tube, EP tube, drug sensitive paper, inoculation loop.

[0044] 1.2 Reagents

[0045] Nutrient Broth (NB, Qingdao High-Tech Park Haibo Biotechnology, batch number: 20101228), agar powder (Qingdao High-Tech Park Haibo Biotechnology, batch number: 20110530), brain heart infusion broth (BHI, Qingdao High-Tech Park Haibo Biotechnology Technology, batch...

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Abstract

The invention discloses an andrographis paniculata hand sanitizer and a preparation method thereof. The andrographis paniculata hand sanitizer has a formula comprising the following raw materials in parts by weight: 0.3 to 3 parts of andrographis paniculata extract, 20 to 50 parts of surface, 1 to 10 parts of propylene glycol, 8 to 15 parts of glycerinum, 1 to 5 parts of essence, 2 to 5 parts of sodium chloride, and 40 to 60 parts of water. According to the andrographis paniculata hand sanitizer, propylene glycol and glycerinum are used together in a certain proportion in the formula, so that the andrographis paniculata extract in the formula can be dissolved fully, and the stability of the hand sanitizer can be kept at a low temperature. The result of an in-vitro drug sensitive test shows that the andrographis paniculata hand sanitizer has a good antibacterial effect.

Description

technical field [0001] The invention relates to the field of chemical compositions, in particular to a Andrographis paniculata hand sanitizer and a preparation method thereof. Background technique [0002] Andrographis paniculata uses the whole herb as medicine, which has the effects of clearing away heat and detoxification, reducing inflammation, reducing swelling and pain, and has anti-inflammatory, antibacterial, antiviral, anticancer, and anticardiovascular diseases. Its medicinal active ingredients are andrographolide, dehydroandrographolide, neoandrographolide, etc., collectively referred to as total andrographolide. According to literature reports, the most stable pH value of andrographolide is 3 to 5, unstable under acidic and alkaline conditions, easy to open ring and hydrolyze, and with the increase of alkalinity, its instability increases; but it is not acidic The stronger the pH, the better the stability. When the pH is lower than 3, the stability is not good. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61Q19/10A61P31/02
Inventor 赖小平张军叶炳煌陈威贺倩童国勇强皎林丽刘国雄邓丽红朱莉汪芳
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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