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Medicine for relieving side effect of normal tissue damage caused by chemotherapy

A side effect, normal technology, used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as hair loss without chemotherapy

Inactive Publication Date: 2013-09-18
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods talk about promoting hair growth, but nothing about preventing hair loss from chemotherapy

Method used

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  • Medicine for relieving side effect of normal tissue damage caused by chemotherapy
  • Medicine for relieving side effect of normal tissue damage caused by chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0020] Embodiment 1: Tone factor prevents alopecia caused by chemotherapy drugs.

[0021] Two-month-old C57BL / 6 mice were taken, and the back skin was depilated with wax to induce hair regeneration. By the ninth day, the hair enters the vigorous growth stage. The chemotherapeutic drug cyclophosphamide (CYP) was dissolved in normal saline and injected intraperitoneally at 150mg / kg body weight. The mice in the control group lost all new hairs on the 20th day (9+11). The experimental group was subcutaneously injected with 1ug / 0.2ml of 1ug / 0.2ml of Sonic factor protein (purchased from R&D Systems, USA, dissolved in normal saline) on days 9+0 and 9+2. As a result, the hair of mice was protected ( figure 1 ).

Embodiment II

[0022] Example II: Halcinonide prevents alopecia induced by chemotherapy drugs.

[0023] Two-month-old C57BL / 6 mice were taken, and the back skin was depilated with wax to induce hair regeneration. By the ninth day, the hair enters the vigorous growth stage. The chemotherapeutic drug cyclophosphamide (CYP) was dissolved in normal saline and injected intraperitoneally at 150mg / kg body weight. The mice in the control group lost all new hairs on the 20th day (9+11). The experimental group took 5ug / 0.2ml of halcinonide solution orally for each mouse on the 9+0, 9+1, and 9+2 consecutive days. As a result, the hair of mice was protected ( figure 1 ).

Embodiment III

[0024] Example III: A variety of chemotherapeutic drugs cause a decrease in the expression of skin tone factor in mice.

[0025] Two-month-old C57BL / 6 mice were taken, and the back skin was depilated with wax to induce hair regeneration. By the ninth day, the hair enters the vigorous growth stage. Chemotherapy drugs (1) cyclophosphamide 150mg / kg; (2) 5-fluorouracil 150mg / kg; (3) paclitaxel 75mg / kg etc. were dissolved, diluted with normal saline, and injected intraperitoneally. Such as figure 2 As shown, compared with pre-administration, the expression level of tone factor in the skin 48 hours after administration decreased significantly.

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PUM

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Abstract

The invention relates to a medicine for relieving a side effect of a normal tissue damage caused by chemotherapy, and aims at providing a Hedgeho therapeutic agent or Shh function substitutes in preparation of a medicine for relieving the side effect of the normal tissue damage caused by chemotherapy, and mainly provides the Hedgeho therapeutic agent or function substitutes thereof in preparation of the medicine for relieving the side effect of the normal tissue damage caused by chemotherapy. Numerous factors or substitutes with the same functions are supplied in the chemotherapy process; the tissue damage caused by the chemotherapy can be relieved and reduced, so as to play a protecting role. A small mice test shows that the medicine disclosed by the invention is significant in effect on relieving and reducing of alopecia caused by the chemotherapy.

Description

technical field [0001] The present invention relates to a medicine for alleviating the side effect of normal tissue damage caused by chemotherapy. Background technique [0002] Cancer patients receive chemotherapy or radiation, often resulting in damage to normal tissue. The most obvious manifestations of these side effects include hair loss, gastrointestinal discomfort, decreased hematopoietic system function and bladder damage. These problems often lead to a serious decline in the quality of life of patients, and even lead to treatment failure. [0003] Current approaches to these issues include (1) 01808658.6 Methods for preventing and treating hair loss induced by chemotherapy or radiation; (2) 200680021549.2 Topical vasoconstrictor preparations and methods for cell protection during cancer chemotherapy and radiation; (3) 200410015898.6 The application of tea polyphenols in the preparation of drugs for the prevention and treatment of alopecia caused by chemotherapy; (4...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K45/00A61K31/56A61K31/58A61K31/573A61P17/14
Inventor 乐志操
Owner FUZHOU UNIV