Plant sterol glycol chitosan targeting vector, preparation method and application thereof

A technology of phytosterol glycol and sterol glycol, applied in the field of structural formula, can solve the problems of toxicity to the body, small molecule antitumor drugs have no tumor tissue targeting effect, etc., and achieve the effect of structural stability

Inactive Publication Date: 2013-09-18
ANHUI NORMAL UNIV
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  • Abstract
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Problems solved by technology

[0004] Antineoplastic drugs are usually small molecule hydrophobic organic substances, and organic solvents need to be added when using them. Organic solvents are toxic to the body. In addition, small molecule antineoplastic drugs have no tumor tissue targeting effect, and they also kill normal cells while inhibiting tumor cells.

Method used

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  • Plant sterol glycol chitosan targeting vector, preparation method and application thereof
  • Plant sterol glycol chitosan targeting vector, preparation method and application thereof
  • Plant sterol glycol chitosan targeting vector, preparation method and application thereof

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Embodiment Construction

[0022] Phytosterol and succinic anhydride react to produce phytosterol hemisuccinic anhydride, and then under the coupling action of N,N'-dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), the phytosterol hemisuccinic anhydride The acid anhydride is connected to the amino group of water-soluble ethylene glycol chitosan to obtain a self-assembled nanopolymer of phytosterol hydrophobically modified ethylene glycol chitosan, and self-assembled phytosterol hydrophobically modified ethylene glycol chitosan in aqueous solution Nanoparticles with a hydrophobic inner core and a hydrophilic outer shell, the hydrophobic inner core can be loaded with hydrophobic anti-tumor drugs, and the targeted delivery of anti-tumor drugs to tumor tissues can be achieved due to the enhanced penetration and retention effects of tumor tissues. Experimental principle such as figure 1 .

[0023] 3.6g of succinic anhydride and 5.5g of phytosterol were mixed and dissolved in 20ml of pyridi...

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Abstract

The invention discloses a plant sterol glycol chitosan targeting vector. The phytosterol glycol chitosan targeting vector is of a spherical nuclear-shell nanoparticle structure, wherein hydrophilic glycol chitosan intertwines to form a spherical shell skeleton of nanoparticles, hydrophobic plant sterol groups form the kernels of the nanoparticles, and the particle diameters of the nanoparticle are not larger than 400nm. The vector and medicine carrying nanoparticles are prepared in a self-assembly method, the prepared medicine vector has a stable structure and has a passive targeting conveyance function on tumor tissues, and the medicine carrying nanoparticles can retain the tumor tissues for a long time to release the medicine for a long time.

Description

technical field [0001] The invention relates to a phytosterol glycol chitosan targeting carrier, specifically a structural formula of [0002] [0003] The phytosterol ethylene glycol chitosan targeting carrier, the preparation method and the doxorubicin / phytosterol ethylene glycol chitosan drug-loaded nanoparticles prepared by the carrier, and the application in antitumor drugs. Background technique [0004] Antineoplastic drugs are usually small-molecule hydrophobic organic substances, which need to be added with organic solvents. Organic solvents are toxic to the body. In addition, small-molecule anti-tumor drugs have no tumor tissue-targeting effect, and can kill normal cells while inhibiting tumor cells. Therefore, there is an urgent need for the development and application of anti-tumor drug carriers that can carry hydrophobic small molecule drugs and have tumor tissue targeting effects. Contents of the invention [0005] The technical problem to be solved by the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36C08B37/08A61K31/704A61K9/19A61P31/00A61P35/00
Inventor 龚仁敏邱叶艳王建婷朱军张健
Owner ANHUI NORMAL UNIV
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