A detection target, primer and reagent for detecting tuberculosis susceptibility

Abstract

The invention provides a detection target, primers, reagents and a kit for detecting tuberculosis susceptibility. The primers are used to detect polymorphisms of EBI3 gene, NOTCH4 gene and BTLA gene in human peripheral blood genomic DNA, and use The above SNP sites are used as targets to design primers, determine the genotype of the sample, and assess the risk of tuberculosis by determining the genotype of the above-mentioned genes in the sample, which provides a new solution for the assessment of the early warning risk of individual tuberculosis.

Description

technical field [0001] The present invention relates to a detection target, primers and reagents for detecting susceptibility to tuberculosis, in particular to a primer for determining the susceptibility of a human body to tuberculosis by detecting polymorphisms of gene loci, and reagents and reagents comprising the primers Reagent test kit. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, and it is a common and fatal infectious disease. Mycobacterium tuberculosis can invade many organs, and pulmonary tuberculosis is the most common form of lung involvement. [0003] After the human body is infected with Mycobacterium tuberculosis, the disease may not necessarily occur. When the resistance is reduced or the cell-mediated allergic reaction is increased, it may cause clinical disease. It is believed that about 1 / 3 of the people in the world are infected with Mycobacterium tuberculosis, but most of the infected p...

AI Technical Summary

Problems solved by technology

Although new anti-tuberculosis drugs have been developed one after another, the current high drug resistance rate of tuberculosis makes tuberculosis still a difficult public health problem

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