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Preparation method for 4-hydroxybenzyl cyanide

The technology of hydroxyphenylacetonitrile and reaction kettle is applied in the directions of cyanide reaction preparation, organic chemistry, etc., and can solve the problems such as low yield of p-hydroxyphenylacetonitrile finished product, low yield of p-hydroxyphenylacetonitrile, and danger in the operation process, etc. Achieve low cost, easy control and operation, and high finished product yield

Active Publication Date: 2013-11-13
TIANJIN KERMEL CHEM REAGENT
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Problems solved by technology

[0002] p-Hydroxyphenylacetonitrile is mostly used as an intermediate in organic synthesis, and it is commonly used to synthesize aminoacidolol. The preparation of p-hydroxyphenylacetonitrile mostly uses an autoclave as a reaction vessel, and hydrogen is used as a reducing agent. The reaction process is difficult to control and the operation process is easy. Danger occurs, and the final yield of p-hydroxybenzonitrile is relatively low; the preparation of p-hydroxybenzonitrile is originally prepared by diazotization method, which has high cost and low yield of p-hydroxybenzonitrile finished product. The preparation method of hydroxyphenylacetonitrile all can not satisfy the demand for p-hydroxyphenylacetonitrile in the market now

Method used

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Embodiment Construction

[0021] The technical solutions of the present invention are described below to facilitate the understanding of those skilled in the art.

[0022] The preparation method of p-hydroxybenzonitrile, the preparation method of p-hydroxybenzonitrile comprises the following two steps:

[0023] (1) Preparation of benzyl alcohol

[0024] ① Put p-hydroxybenzaldehyde as raw material into the reaction kettle, add methanol as solvent into the reaction kettle, then add an appropriate amount of water into the reaction kettle, and stir evenly;

[0025] ② Slowly add potassium borohydride to the reaction kettle in the above (1) step ①, monitor the temperature of the reaction kettle at 30-35°C, and react;

[0026] 3. Add acidic solution to the reaction kettle in the above (1) 2. step, and adjust the reaction kettle solution to neutrality;

[0027] ④ Centrifuge the reacted material in the reactor in the above (1) ③ step, remove the solution to obtain the crude benzyl alcohol, dry the crude benzy...

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Abstract

The invention belongs to the field of organic chemistry synthesis, and specifically relates to the field of preparation of 4-hydroxybenzyl cyanide. A preparation method for 4-hydroxybenzyl cyanide comprises preparation of benzylalcohol and preparation of 4-hydroxybenzyl cyanide by employing 4-hydroxybenzaldehyde as a raw material and potassium borohydride as a reducing agent. The preparation method for 4-hydroxybenzyl cyanide is performed at normal temperature and normal pressure; the operation process is fast, simple and easy to control; the reaction time in the preparation process is shorter; and the yield of the finished product of 4-hydroxybenzyl cyanide is 95% or more.

Description

technical field [0001] The invention belongs to the field of organic chemical synthesis, and more specifically relates to the field of preparation of p-hydroxyphenylacetonitrile. technical background [0002] p-Hydroxyphenylacetonitrile is mostly used as an intermediate in organic synthesis, and it is commonly used to synthesize aminoacidolol. The preparation of p-hydroxyphenylacetonitrile mostly uses an autoclave as a reaction vessel, and hydrogen is used as a reducing agent. The reaction process is difficult to control and the operation process is easy. Danger occurs, and the final yield of p-hydroxybenzonitrile is relatively low; the preparation of p-hydroxybenzonitrile is originally prepared by diazotization method, which has high cost and low yield of p-hydroxybenzonitrile finished product. The preparation method of hydroxyphenylacetonitrile all can not well satisfy the demand for p-hydroxyphenylacetonitrile in the market now. Contents of the invention [0003] The t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C255/36C07C253/16
Inventor 卢益民
Owner TIANJIN KERMEL CHEM REAGENT
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