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Cefprozil tablet and preparation method thereof

A technology for cefprozil and propylene tablets, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low dissolution rate, difficulty in meeting quality requirements, poor stability, etc. , to achieve the effect of simple steps, reduced ring-opening degradation, good stability and dissolution

Active Publication Date: 2015-04-29
NORTH CHINA PHARMA HEBEI HUAMIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can avoid the hydrolysis of cefprozil, when the obtained tablet is placed for a long time, the stability is not good enough, the dissolution rate is low, and it is difficult to meet the quality requirements under the long-term storage conditions of the drug.
At present, there is a lack of a cefprozil preparation that can maintain good stability and dissolution rate during preparation and long-term storage, and has a simple and economical preparation method

Method used

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  • Cefprozil tablet and preparation method thereof
  • Cefprozil tablet and preparation method thereof
  • Cefprozil tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] According to the following formula, prepare cefprozil tablet, batch number is 142111102.

[0037]

[0038]

[0039] The preparation steps are as follows:

[0040] (1) Sieve

[0041] Cefprozil, crospovidone, and microcrystalline cellulose are passed through 80 mesh sieves respectively, and lactose is directly pressed through a 60 mesh sieve to collect the powder under the sieve; wherein, the purity of cefprozil is 96.3%; the model of microcrystalline cellulose is Microcrystalline Cellulose 101.

[0042] (2) premixed

[0043] Weigh the cefprozil, microcrystalline cellulose, direct-pressed lactose, and crospovidone that have been sieved in step (1), add them into the mixer, and pre-mix for 10 minutes;

[0044] (3) total mix

[0045] Weigh magnesium stearate and silicon dioxide respectively, add them into the mixer described in step (2), and mix for 10 minutes.

[0046] After mixing, insert the sampling probe into the upper, middle and lower parts of the mixer bu...

Embodiment 2

[0063] According to the following formula, prepare cefprozil tablet, batch number is 142111103.

[0064]

[0065] The preparation steps are as follows:

[0066] (1) Sieve

[0067] Cefprozil, crospovidone, and microcrystalline cellulose are passed through 80 mesh sieves respectively, and lactose is directly pressed through a 60 mesh sieve to collect the powder under the sieve; wherein, the purity of cefprozil is 96.3%; the model of microcrystalline cellulose is Microcrystalline Cellulose 101.

[0068] (2) premixed

[0069] Weigh the cefprozil, microcrystalline cellulose, direct-pressed lactose, and crospovidone that have been sieved in step (1), add them into the mixer, and pre-mix for 10 minutes;

[0070] (3) total mix

[0071] Weigh magnesium stearate and silicon dioxide respectively, add them into the mixer described in step (2), and mix for 10 minutes.

[0072] After mixing, insert the sampling probe into the upper, middle and lower parts of the mixer bucket, and take...

Embodiment 3

[0085] According to the following formula, prepare cefprozil tablet, batch number is 142111104.

[0086]

[0087] The preparation steps are as follows:

[0088] (1) Sieve

[0089] Cefprozil, crospovidone, and microcrystalline cellulose are passed through 80 mesh sieves respectively, and lactose is directly pressed through a 60 mesh sieve to collect the powder under the sieve; wherein, the purity of cefprozil is 96.3%; the model of microcrystalline cellulose is Microcrystalline Cellulose 101.

[0090] (2) premixed

[0091] Weigh the cefprozil, microcrystalline cellulose, direct-pressed lactose, and crospovidone that have been sieved in step (1), add them into the mixer, and pre-mix for 10 minutes;

[0092] (3) total mix

[0093] Weigh magnesium stearate and silicon dioxide respectively, add them into the mixer described in step (2), and mix for 10 minutes.

[0094] After mixing, insert the sampling probe into the upper, middle and lower parts of the mixer bucket, and ta...

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Abstract

The invention provides a cefprozil tablet which comprises a tablet core and a thin-film coating. The cefprozil tablet is characterized in that the tablet core is composed of cefprozil and medicinal excipients, and the medicinal excipients include microcrystalline cellulose, vertical-compression lactose, cross-linked polyvinylpolypyrrolidone, magnesium stearate and silicon dioxide. The invention further provides a preparation method of the cefprozil tablet. The preparation method includes under the conditions that the temperature is 18 DEG C-26 DEG C and relative humidity is 45-65%, sieving, premixing, tableting and coating. The cefprozil tablet prepared by the method can maintain high stability and dissolubility in the process of preparation and long-term storage.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a tablet of cefprozil and a preparation method thereof. Background technique [0002] Cefprozil is a second-generation cephalosporin oral broad-spectrum antibiotic, and its mechanism of action is to inhibit the synthesis of bacterial cell walls. Cefprozil has the advantages of strong antibacterial effect, resistance to penicillinase, good clinical curative effect, low toxicity, and less allergic reaction than penicillin. Its structural formula is as follows: [0003] [0004] Similar to other cephalosporins, cefprozil contains a β-lactam ring in its molecular structure. The β-lactam ring is the most unstable part in the structure of this type of compound. If the ring is broken, the antibacterial effect will disappear. Usually, when encountering acid, alkali or β-lactamase, cefprozil is prone to undergo hydrolysis ring opening and lose antibac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K31/545A61K47/38A61P31/04
Inventor 李艳敏郭洪茹张莉柳世萍刘东张锁庆刘海席王朝卿张文盛李敏
Owner NORTH CHINA PHARMA HEBEI HUAMIN PHARMA
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