Multilayer composite hemostatic material and preparation method thereof
A hemostatic material, multi-layer composite technology, applied in the field of pharmaceuticals, to achieve the effect of easy access, expanding the application range, and increasing the thickness of the material
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[0042] It can be prepared by patent and literature methods. For details, please refer to the preparation method of Chinese patent ZL200810100981.1 pure sodium alginate nanofiber membrane material and the literature Biomacromolecules2008, 9, 1362-1365. The specific steps are: mix alginate and glycerin at a weight-to-volume ratio of 2-4g / ml, then add solvent water to the mixture, wherein the volume ratio of water to glycerin is 0.5-1:1, stir evenly, and stand still Remove air bubbles to obtain spinning stock solution, the flow rate of spinning stock solution is 50-200μl / h, the solution flow rate is precisely controlled by a syringe pump, the spinning voltage is adjusted between 10-40kV, the distance between the spinneret and the receiver is 5-15cm, The receiver is soaked in a CaCl 2 In a coagulation bath composed of aqueous solution and absolute ethanol, the collection time is 36-72 hours, and the thickness of the collected fiber web is continuously adjustable from several hundr...
Embodiment 1
[0058] Embodiment 1 (preparation of No. 1 sample)
[0059] (1) Preparation of gelatin hollow nanofiber web material
[0060] A coaxial spinning needle was used in the spinning experiment, and its specification was that the inner diameter of the inner needle was 0.3 mm, and the inner diameter of the outer needle was 1.2 mm. Gelatin is used as raw material and formic acid is used as solvent. Dissolve gelatin in formic acid at room temperature. The stirred solution is uniform and transparent. The mass fraction of gelatin is 20%. This solution is the shell solution of coaxial spinning. Nucleus solution uses sesame oil. The above solution was left to remove air bubbles as the spinning stock solution, and injected into the syringe. The flow rate of the shell layer solution was 0.6ml / h, and the flow rate of the core layer solution was 0.3ml / h. The solution flow rate was precisely controlled by a syringe pump. Under the conditions of 22kV voltage, the distance between the spinneret ...
Embodiment 2
[0071] Embodiment 2 (preparation of No. 2 sample)
[0072] (1) Preparation of gelatin hollow nanofiber web material
[0073] In the preparation of the spinning stock solution, the mass fraction of the gelatin solution was set to 16%; during coaxial spinning, the flow rate of the shell solution was set to 0.5ml / h, the flow rate of the core layer solution was set to 0.2ml / h, and the spinning voltage Set it to 15kV, set the collection time to 36 hours, and the others are the same as in Example 1. The thickness of the collected web material was about 1.5 mm.
[0074] (2) Preparation of sodium alginate nanofiber web material
[0075] In the preparation of the spinning stock solution, the weight-to-volume ratio of sodium alginate and glycerin was set to 3g / ml, and the volume ratio of water to glycerin was set to 0.5:1; during electrospinning, the voltage was set to 28kV, and the flow rate was set to 100μl / ml. h, the distance between the spinneret and the receiver is set to 12cm, ...
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